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Title: CorDiffViz: an R package for visualizing multi-omics differential correlation networks
Abstract Background

Differential correlation networks are increasingly used to delineate changes in interactions among biomolecules. They characterize differences between omics networks under two different conditions, and can be used to delineate mechanisms of disease initiation and progression.

 Results

We present a new R package, , that facilitates the estimation and visualization of differential correlation networks using multiple correlation measures and inference methods. The software is implemented in , and , and is available athttps://github.com/sqyu/CorDiffViz. Visualization has been tested for the Chrome and Firefox web browsers. A demo is available athttps://diffcornet.github.io/CorDiffViz/demo.html.

 Conclusions

Our software offers considerable flexibility by allowing the user to interact with the visualization and choose from different estimation methods and visualizations. It also allows the user to easily toggle between correlation networks for samples under one condition and differential correlations between samples under two conditions. Moreover, the software facilitates integrative analysis of cross-correlation networks between two omics data sets.

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NSF-PAR ID:
10306082
Author(s) / Creator(s):
; ; ;
Publisher / Repository:
Springer Science + Business Media
Date Published:
Journal Name:
BMC Bioinformatics
Volume:
22
Issue:
1
ISSN:
1471-2105
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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