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Adhesive hydrogels with tunable mechanical properties and strong adhesion to wet, dynamic tissues have emerged as promising materials for tissue repair, with potential applications in wound closure, hemorrhage control, and surgical adhesives. This review highlights the key design principles, material classifications, and recent advances in adhesive hydrogels designed for vascular repair. The limitations of existing adhesive hydrogels, including insufficient mechanical durability, suboptimal biocompatibility, and challenges in targeted delivery, are critically evaluated. Furthermore, innovative strategies—such as incorporating self-healing capabilities, developing stimuli-responsive systems, integrating functional nanocomposites, and employing advanced fabrication techniques like 3D bioprinting—are discussed to enhance adhesion, mechanical stability, and vascular tissue regeneration. While significant progress has been made, further research and optimization are necessary to advance these materials toward clinical translation, offering a versatile and minimally invasive alternative to traditional vascular repair techniques.
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Biomimetic Adhesive for Biomedical Applications: A Review
This study aimed to provide a review of the current status of the biomimetic adhesives that have the potential for clinical application. Biomimetic materials emulate compounds and properties with a biological origin. They have grown to be more relevant in medical fields due to biocompatibility, low toxicity, and a less damaging impact on the environment. Bonding living tissues has proved to be difficult due to the adverse immune reactions to foreign materials and the wet environment of the damaged area. There is a need for biomimetic adhesives due to the shortcomings of synthetic adhesives and metal tools required for wound closure. Despite differences in developmental approaches and organismal properties, the biomimetic adhesives developed have the potential to be used in wet environments with enough strength to help bond the tissues together without any supporting materials.
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- Award ID(s):
- 2000061
- PAR ID:
- 10311870
- Date Published:
- Journal Name:
- Trends in Biomaterials and Artificial Organs
- Volume:
- 35
- Issue:
- 5
- ISSN:
- 0971-1198
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Accepted Manuscript1.0
- Journal Article:
- The DOI is not currently available.
