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This study examines the interactions between healthy target cells, infected target cells, virus particles, and immune cells within an HIV model. The model exhibits two equilibrium points: an infection-free equilibrium and an infection equilibrium. Stability analysis shows that the infection-free equilibrium is locally asymptotically stable when R0<1. Further, it is unstable when R0>1. The infection equilibrium is locally asymptotically stable when R0>1. The structural and practical identifiabilities of the within-host model for HIV infection dynamics were investigated using differential algebra techniques and Monte Carlo simulations. The HIV model was structurally identifiable by observing the total uninfected and infected target cells, immune cells, and viral load. Monte Carlo simulations assessed the practical identifiability of parameters. The production rate of target cells (λ), the death rate of healthy target cells (d), the death rate of infected target cells (δ), and the viral production rate by infected cells (π) were practically identifiable. The rate of infection of target cells by the virus (β), the death rate of infected cells by immune cells (Ψ), and antigen-driven proliferation rate of immune cells (b) were not practically identifiable. Practical identifiability was constrained by the noise and sparsity of the data. Analysis shows that increasing the frequency of data collection can significantly improve the identifiability of all parameters. This highlights the importance of optimal data sampling in HIV clinical studies, as it determines the best time points, frequency, and the number of sample points required to accurately capture the dynamics of the HIV infection within a host.
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Data-Driven Distributed Mitigation Strategies and Analysis of Mutating Epidemic Processes
In this paper we study a discrete-time SIS (susceptible-infected-susceptible) model, where the infection and healing parameters and the underlying network may change over time. We provide conditions for the model to be well-defined and study its stability. For systems with homogeneous infection rates over symmetric graphs, we provide a sufficient condition for global exponential stability (GES) of the healthy state, that is, where the virus is eradicated. For systems with heterogeneous virus spread over directed graphs, provided that the variation is not too fast, a sufficient condition for GES of the healthy state is established. Appealing to the first stability result, we present two data-driven mitigation strategies that set the healing parameters in a centralized and a distributed manner, respectively, in order to drive the system to the healthy state.
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- Award ID(s):
- 2028738
- PAR ID:
- 10320296
- Date Published:
- Journal Name:
- 2020 59th IEEE Conference on Decision and Control (CDC)
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Conference Paper:
- https://doi.org/10.1109/CDC42340.2020.9304040
