More Like this

1. A 65nm Resonant Electro-Quasistatic 5-240uW Human Whole-Body Powering and 2.19uW Communication SoC with Automatic Maximum Resonant Power Tracking

   https://doi.org/10.1109/CICC51472.2021.9431456  

   Modak, Nirmoy ; Das, Debayan ; Nath, Mayukh ; Chatterjee, Baibhab ; Gaurav Kumar, K ; Maity, Shovan ; Sen, Shreyas ( April 2021 , 2021 IEEE Custom Integrated Circuits Conference (CICC))

   Applications like Connected Healthcare through physiological signal monitoring and Secure Authentication using wearable keys can benefit greatly from battery-less operation. Low power communication along with energy harvesting is critical to sustain such perpetual battery-less operation. Previous studies have used techniques such as Tribo-Electric, Piezo-Electric, RF energy harvesting for Body Area Network devices, but they are restricted to on-body node placements. Human body channel is known to be a promising alternative to wireless radio wave communication for low power operation [1-4], through Human Body Communication, as well as very recently as a medium for power transfer through body coupled power transfer [5]. However, channel length (L) dependency of the received power makes it inefficient for L>40cm. There have also been a few studies for low power communication through the human body, but none of them could provide sustainable battery-less operation. In this paper, we utilize Resonant Electro Quasi-Static Human Body Communication (Res-EQS HBC) with Maximum Resonance Power Tracking (MRPT) to enable channel length independent whole-body communication and powering (Fig.1). We design the first system to simultaneously transfer Power and Data between a HUB device and a wearable through the human body to enable battery-less operation. Measurement results show 240uW, 28uW and 5uW power transfer through the body in a MachineMachine (large devices with strong ground connection) Tabletop (small devices kept on a table, as in [5]) and Wearable-Wearable (small form factor battery operated devices) scenario respectively, independent of body channel length, while enabling communication with a power consumption of only 2.19uW. This enables >25x more power transfer with >100x more efficiency compared to [5] for Tabletop and 100cm Body distance by utilizing the benefits of EQS. The MRPT loop automatically tracks device and posture dependent resonance point changes to maximize power transfer in all cases. 

   more » « less
2. Enabling Covert Body Area Network using Electro-Quasistatic Human Body Communication

   https://doi.org/10.1038/s41598-018-38303-x  

   Das, Debayan ; Maity, Shovan ; Chatterjee, Baibhab ; Sen, Shreyas ( March 2019 , Scientific Reports)

   Radiative communication using electro-magnetic (EM) fields amongst the wearable and implantable devices act as the backbone for information exchange around a human body, thereby enabling prime applications in the fields of connected healthcare, electroceuticals, neuroscience, augmented and virtual reality. However, owing to such radiative nature of the traditional wireless communication, EM signals propagate in all directions, inadvertently allowing an eavesdropper to intercept the information. In this context, the human body, primarily due to its high water content, has emerged as a medium for low-loss transmission, termed human body communication (HBC), enabling energy-efficient means for wearable communication. However, conventional HBC implementations suffer from significant radiation which also compromises security. In this article, we present Electro-Quasistatic Human Body Communication (EQS-HBC), a method for localizing signals within the body using low-frequency carrier-less (broadband) transmission, thereby making it extremely difficult for a nearby eavesdropper to intercept critical private data, thus producing a covert communication channel, i.e. the human body. This work, for the first time, demonstrates and analyzes the improvement in private space enabled by EQS-HBC. Detailed experiments, supported by theoretical modeling and analysis, reveal that the quasi-static (QS) leakage due to the on-body EQS-HBC transmitter-human body interface is detectable up to <0.15 m, whereas the human body alone leaks only up to ~0.01 m, compared to >5 mdetection range for on-body EM wireless communication, highlighting the underlying advantage of EQS-HBC to enable covert communication.

    

   more » « less
3. A 415 nW Physically and Mathematically Secure Electro-Quasistatic HBC Node in 65nm CMOS for Authentication and Medical Applications

   https://doi.org/10.1109/CICC48029.2020.9075930  

   Maity, Shovan ; Modak, Nirmoy ; Yang, David ; Avlani, Shitij ; Nath, Mayukh ; Danial, Josef ; Das, Debayan ; Mehrotra, Parikha ; Sen, Shreyas ( April 2020 , IEEE Custom Integrated Circuits Conference (CICC))

   null (Ed.)

   Applications such as secure authentication, remote health monitoring require secure, low power communication between devices around the body. Radio wave communication protocols, such as Bluetooth, suffer from the problem of signal leakage and high power requirement. Electro Quasistatic Human Body Communication (EQS-UBC) is the ideal alternative as it confines the signal within the body and also operates at order of magnitude lower power. In this paper, we design a secure HBC SoC node, which uses EQS-UBC for physical security and an AES-256 core for mathematical security. The SoC consumes 415nW power with an active power of 108nW for a data rate of 1kbps, sufficient for authentication and remote monitoring applications. This translates to 100x improvement in power consumption compared to state-of-the-art HBC implementations while providing physical security for the first time. 

   more » « less
4. BodyWire-HCI: Enabling New Interaction Modalities by Communicating Strictly During Touch Using Electro-Quasistatic Human Body Communication

   https://doi.org/10.1145/3406238  

   Maity, Shovan ; Yang, David ; Redford, Scott Stanton ; Das, Debayan ; Chatterjee, Baibhab ; Sen, Shreyas ( December 2020 , ACM Transactions on Computer-Human Interaction)

   null (Ed.)

   Communication during touch provides a seamless and natural way of interaction between humans and ambient intelligence. Current techniques that couple wireless transmission with touch detection suffer from the problem of selectivity and security, i.e., they cannot ensure communication only through direct touch and not through close proximity. We present  BodyWire-HCI , which utilizes the human body as a wire-like communication channel, to enable human–computer interaction, that for the first time, demonstrates selective and physically secure communication strictly during touch. The signal leakage out of the body is minimized by utilizing a novel, low frequency Electro-QuasiStatic Human Body Communication (EQS-HBC) technique that enables interaction strictly when there is a conductive communication path between the transmitter and receiver through the human body. Design techniques such as capacitive termination and voltage mode operation are used to minimize the human body channel loss to operate at low frequencies and enable EQS-HBC. The demonstrations highlight the impact of  BodyWire-HCI in enabling new human–machine interaction modalities for variety of application scenarios such as secure authentication (e.g., opening a door and pairing a smart device) and information exchange (e.g., payment, image, medical data, and personal profile transfer) through touch (https://www.youtube.com/watch?v=Uwrig2XQIH8). 

   more » « less
5. The Temple University Digital Pathology Corpus: The Breast Tissue Subset

   https://doi.org/10.1109/SPMB52430.2021.9672275  

   Wevodau, Z. ; Doshna, B. ; Jhala, N. ; Akhtar, I. ; Obeid, I. ; Picone, J. ( December 2021 , Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB))

   Obeid, I. (Ed.)

   The Neural Engineering Data Consortium (NEDC) is developing the Temple University Digital Pathology Corpus (TUDP), an open source database of high-resolution images from scanned pathology samples [1], as part of its National Science Foundation-funded Major Research Instrumentation grant titled “MRI: High Performance Digital Pathology Using Big Data and Machine Learning” [2]. The long-term goal of this project is to release one million images. We have currently scanned over 100,000 images and are in the process of annotating breast tissue data for our first official corpus release, v1.0.0. This release contains 3,505 annotated images of breast tissue including 74 patients with cancerous diagnoses (out of a total of 296 patients). In this poster, we will present an analysis of this corpus and discuss the challenges we have faced in efficiently producing high quality annotations of breast tissue. It is well known that state of the art algorithms in machine learning require vast amounts of data. Fields such as speech recognition [3], image recognition [4] and text processing [5] are able to deliver impressive performance with complex deep learning models because they have developed large corpora to support training of extremely high-dimensional models (e.g., billions of parameters). Other fields that do not have access to such data resources must rely on techniques in which existing models can be adapted to new datasets [6]. A preliminary version of this breast corpus release was tested in a pilot study using a baseline machine learning system, ResNet18 [7], that leverages several open-source Python tools. The pilot corpus was divided into three sets: train, development, and evaluation. Portions of these slides were manually annotated [1] using the nine labels in Table 1 [8] to identify five to ten examples of pathological features on each slide. Not every pathological feature is annotated, meaning excluded areas can include focuses particular to these labels that are not used for training. A summary of the number of patches within each label is given in Table 2. To maintain a balanced training set, 1,000 patches of each label were used to train the machine learning model. Throughout all sets, only annotated patches were involved in model development. The performance of this model in identifying all the patches in the evaluation set can be seen in the confusion matrix of classification accuracy in Table 3. The highest performing labels were background, 97% correct identification, and artifact, 76% correct identification. A correlation exists between labels with more than 6,000 development patches and accurate performance on the evaluation set. Additionally, these results indicated a need to further refine the annotation of invasive ductal carcinoma (“indc”), inflammation (“infl”), nonneoplastic features (“nneo”), normal (“norm”) and suspicious (“susp”). This pilot experiment motivated changes to the corpus that will be discussed in detail in this poster presentation. To increase the accuracy of the machine learning model, we modified how we addressed underperforming labels. One common source of error arose with how non-background labels were converted into patches. Large areas of background within other labels were isolated within a patch resulting in connective tissue misrepresenting a non-background label. In response, the annotation overlay margins were revised to exclude benign connective tissue in non-background labels. Corresponding patient reports and supporting immunohistochemical stains further guided annotation reviews. The microscopic diagnoses given by the primary pathologist in these reports detail the pathological findings within each tissue site, but not within each specific slide. The microscopic diagnoses informed revisions specifically targeting annotated regions classified as cancerous, ensuring that the labels “indc” and “dcis” were used only in situations where a micropathologist diagnosed it as such. Further differentiation of cancerous and precancerous labels, as well as the location of their focus on a slide, could be accomplished with supplemental immunohistochemically (IHC) stained slides. When distinguishing whether a focus is a nonneoplastic feature versus a cancerous growth, pathologists employ antigen targeting stains to the tissue in question to confirm the diagnosis. For example, a nonneoplastic feature of usual ductal hyperplasia will display diffuse staining for cytokeratin 5 (CK5) and no diffuse staining for estrogen receptor (ER), while a cancerous growth of ductal carcinoma in situ will have negative or focally positive staining for CK5 and diffuse staining for ER [9]. Many tissue samples contain cancerous and non-cancerous features with morphological overlaps that cause variability between annotators. The informative fields IHC slides provide could play an integral role in machine model pathology diagnostics. Following the revisions made on all the annotations, a second experiment was run using ResNet18. Compared to the pilot study, an increase of model prediction accuracy was seen for the labels indc, infl, nneo, norm, and null. This increase is correlated with an increase in annotated area and annotation accuracy. Model performance in identifying the suspicious label decreased by 25% due to the decrease of 57% in the total annotated area described by this label. A summary of the model performance is given in Table 4, which shows the new prediction accuracy and the absolute change in error rate compared to Table 3. The breast tissue subset we are developing includes 3,505 annotated breast pathology slides from 296 patients. The average size of a scanned SVS file is 363 MB. The annotations are stored in an XML format. A CSV version of the annotation file is also available which provides a flat, or simple, annotation that is easy for machine learning researchers to access and interface to their systems. Each patient is identified by an anonymized medical reference number. Within each patient’s directory, one or more sessions are identified, also anonymized to the first of the month in which the sample was taken. These sessions are broken into groupings of tissue taken on that date (in this case, breast tissue). A deidentified patient report stored as a flat text file is also available. Within these slides there are a total of 16,971 total annotated regions with an average of 4.84 annotations per slide. Among those annotations, 8,035 are non-cancerous (normal, background, null, and artifact,) 6,222 are carcinogenic signs (inflammation, nonneoplastic and suspicious,) and 2,714 are cancerous labels (ductal carcinoma in situ and invasive ductal carcinoma in situ.) The individual patients are split up into three sets: train, development, and evaluation. Of the 74 cancerous patients, 20 were allotted for both the development and evaluation sets, while the remain 34 were allotted for train. The remaining 222 patients were split up to preserve the overall distribution of labels within the corpus. This was done in hope of creating control sets for comparable studies. Overall, the development and evaluation sets each have 80 patients, while the training set has 136 patients. In a related component of this project, slides from the Fox Chase Cancer Center (FCCC) Biosample Repository (https://www.foxchase.org/research/facilities/genetic-research-facilities/biosample-repository -facility) are being digitized in addition to slides provided by Temple University Hospital. This data includes 18 different types of tissue including approximately 38.5% urinary tissue and 16.5% gynecological tissue. These slides and the metadata provided with them are already anonymized and include diagnoses in a spreadsheet with sample and patient ID. We plan to release over 13,000 unannotated slides from the FCCC Corpus simultaneously with v1.0.0 of TUDP. Details of this release will also be discussed in this poster. Few digitally annotated databases of pathology samples like TUDP exist due to the extensive data collection and processing required. The breast corpus subset should be released by November 2021. By December 2021 we should also release the unannotated FCCC data. We are currently annotating urinary tract data as well. We expect to release about 5,600 processed TUH slides in this subset. We have an additional 53,000 unprocessed TUH slides digitized. Corpora of this size will stimulate the development of a new generation of deep learning technology. In clinical settings where resources are limited, an assistive diagnoses model could support pathologists’ workload and even help prioritize suspected cancerous cases. ACKNOWLEDGMENTS This material is supported by the National Science Foundation under grants nos. CNS-1726188 and 1925494. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. REFERENCES [1] N. Shawki et al., “The Temple University Digital Pathology Corpus,” in Signal Processing in Medicine and Biology: Emerging Trends in Research and Applications, 1st ed., I. Obeid, I. Selesnick, and J. Picone, Eds. New York City, New York, USA: Springer, 2020, pp. 67 104. https://www.springer.com/gp/book/9783030368432. [2] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning.” Major Research Instrumentation (MRI), Division of Computer and Network Systems, Award No. 1726188, January 1, 2018 – December 31, 2021. https://www. isip.piconepress.com/projects/nsf_dpath/. [3] A. Gulati et al., “Conformer: Convolution-augmented Transformer for Speech Recognition,” in Proceedings of the Annual Conference of the International Speech Communication Association (INTERSPEECH), 2020, pp. 5036-5040. https://doi.org/10.21437/interspeech.2020-3015. [4] C.-J. Wu et al., “Machine Learning at Facebook: Understanding Inference at the Edge,” in Proceedings of the IEEE International Symposium on High Performance Computer Architecture (HPCA), 2019, pp. 331–344. https://ieeexplore.ieee.org/document/8675201. [5] I. Caswell and B. Liang, “Recent Advances in Google Translate,” Google AI Blog: The latest from Google Research, 2020. [Online]. Available: https://ai.googleblog.com/2020/06/recent-advances-in-google-translate.html. [Accessed: 01-Aug-2021]. [6] V. Khalkhali, N. Shawki, V. Shah, M. Golmohammadi, I. Obeid, and J. Picone, “Low Latency Real-Time Seizure Detection Using Transfer Deep Learning,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2021, pp. 1 7. https://www.isip. piconepress.com/publications/conference_proceedings/2021/ieee_spmb/eeg_transfer_learning/. [7] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning,” Philadelphia, Pennsylvania, USA, 2020. https://www.isip.piconepress.com/publications/reports/2020/nsf/mri_dpath/. [8] I. Hunt, S. Husain, J. Simons, I. Obeid, and J. Picone, “Recent Advances in the Temple University Digital Pathology Corpus,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2019, pp. 1–4. https://ieeexplore.ieee.org/document/9037859. [9] A. P. Martinez, C. Cohen, K. Z. Hanley, and X. (Bill) Li, “Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ,” Arch. Pathol. Lab. Med., vol. 140, no. 7, pp. 686–689, Apr. 2016. https://doi.org/10.5858/arpa.2015-0238-OA. 

   more » « less