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Title: Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers
We have developed a microfluidic platform for engineering cardiac microtissues in highly-controlled microenvironments. The platform is fabricated using direct laser writing (DLW) lithography and soft lithography, and contains four separate devices. Each individual device houses a cardiac microtissue and is equipped with an integrated strain actuator and a force sensor. Application of external pressure waves to the platform results in controllable time-dependent forces on the microtissues. Conversely, oscillatory forces generated by the microtissues are transduced into measurable electrical outputs. We demonstrate the capabilities of this platform by studying the response of cardiac microtissues derived from human induced pluripotent stem cells (hiPSC) under prescribed mechanical loading and pacing. This platform will be used for fundamental studies and drug screening on cardiac microtissues.  more » « less
Award ID(s):
1647837
PAR ID:
10331881
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Date Published:
Journal Name:
Lab on a Chip
Volume:
21
Issue:
9
ISSN:
1473-0197
Page Range / eLocation ID:
1724 to 1737
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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