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  • Annealing post-drawn polycaprolactone (PCL) nanofibers optimizes crystallinity and molecular alignment and enhances mechanical properties and drug release profiles
Title: Annealing post-drawn polycaprolactone (PCL) nanofibers optimizes crystallinity and molecular alignment and enhances mechanical properties and drug release profiles
Post-drawn PCL nanofibers can be molecularly tuned to have a variety of mechanical properties and drug release profiles depending on the temperature and time of annealing, which has implications for regenerative medicine and drug delivery applications. Post-drawing polycaprolactone (PCL) nanofibers has previously been demonstrated to drastically increase their mechanical properties. Here the effects of annealing on post-drawn PCL nanofibers are characterized. It is shown that room temperature storage and in vivo temperatures increase crystallinity significantly on the order of weeks, and that high temperature annealing near melt significantly increases crystallinity and molecular orientation on the order of minutes. The kinetics of crystallization were assessed using an anneal and quench approach. High temperature annealing also increased the ultimate tensile strength and toughness of the fibers and changed the release profile of a model drug absorbed in PCL nanofibers from first-order to zero-order kinetics.  more » « less
Award ID(s):
1653329
PAR ID:
10333435
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
Materials Advances
Volume:
3
Issue:
7
ISSN:
2633-5409
Page Range / eLocation ID:
3303 to 3315
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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