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Title: Deep Learning of Material Transport in Complex Neurite Networks
Neurons exhibit complex geometry in their branched networks of neurites which is essential to the function of individual neuron but also brings challenges to transport a wide variety of essential materials throughout their neurite networks for their survival and function. While numerical methods like isogeometric analysis (IGA) have been used for modeling the material transport process via solving partial differential equations (PDEs), they require long computation time and huge computation resources to ensure accurate geometry representation and solution, thus limit their biomedical application. Here we present a graph neural network (GNN)-based deep learning model to learn the IGA-based material transport simulation and provide fast material concentration prediction within neurite networks of any topology. Given input boundary conditions and geometry configurations, the well-trained model can predict the dynamical concentration change during the transport process with an average error less than 10% and 120∼330 times faster compared to IGA simulations. The effectiveness of the proposed model is demonstrated within several complex neurite networks.  more » « less
Award ID(s):
2227232
PAR ID:
10335583
Author(s) / Creator(s):
; ;
Date Published:
Journal Name:
Scientific reports
Volume:
11
ISSN:
2045-2322
Page Range / eLocation ID:
11280
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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