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Title: 2-Guanidyl pyridine PNA nucleobase for triple-helical Hoogsteen recognition of cytosine in double-stranded RNA
In triplex-forming peptide nucleic acid, a novel 2-guanidyl pyridine nucleobase (V) enables recognition of up to two cytosine interruptions in polypurine tracts of dsRNA by engaging the entire Hoogsteen face of C–G base pair. Ab initio and molecular dynamics simulations provided insights into H-bonding interactions that stabilized V·C–G triplets. Our results provided insights for future design of improved nucleobases, which is an important step towards the ultimate goal of recognition of any sequence of dsRNA.  more » « less
Award ID(s):
2107900
PAR ID:
10336484
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Chemical Communications
Volume:
58
Issue:
51
ISSN:
1359-7345
Page Range / eLocation ID:
7148 to 7151
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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