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Title: TOWARDS INTERPRETING ZOONOTIC POTENTIAL OF BETACORONAVIRUS SEQUENCES WITH ATTENTION
Current methods for viral discovery target evolutionarily conserved proteins that accurately identify virus families but remain unable to distinguish the zoonotic potential of newly discovered viruses. Here, we apply an attention-enhanced longshort- term memory (LSTM) deep neural net classifier to a highly conserved viral protein target to predict zoonotic potential across betacoronaviruses. The classifier performs with a 94% accuracy. Analysis and visualization of attention at the sequence and structure-level features indicate possible association between important protein-protein interactions governing viral replication in zoonotic betacoronaviruses and zoonotic transmission.  more » « less
Award ID(s):
1717282
NSF-PAR ID:
10350220
Author(s) / Creator(s):
; ; ; ; ; ;
Date Published:
Journal Name:
ICLR
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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