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Title: Recent insights into mechanisms preventing ectopic centromere formation
The centromere is a specialized chromosomal structure essential for chromosome segregation. Centromere dysfunction leads to chromosome segregation errors and genome instability. In most eukaryotes, centromere identity is specified epigenetically by CENP-A, a centromere-specific histone H3 variant. CENP-A replaces histone H3 in centromeres, and nucleates the assembly of the kinetochore complex. Mislocalization of CENP-A to non-centromeric regions causes ectopic assembly of CENP-A chromatin, which has a devastating impact on chromosome segregation and has been linked to a variety of human cancers. How non-centromeric regions are protected from CENP-A misincorporation in normal cells is largely unexplored. Here, we review the most recent advances on the mechanisms underlying the prevention of ectopic centromere formation, and discuss the implications in human disease.  more » « less
Award ID(s):
1934628
NSF-PAR ID:
10354526
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Open Biology
Volume:
11
Issue:
9
ISSN:
2046-2441
Page Range / eLocation ID:
210189
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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