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Title: Tumor models in various Drosophila tissues
Abstract

The development of cancer is a complex multistage process. Over the past few decades, the model organismDrosophila melanogasterhas been crucial in identifying cancer‐related genes and pathways and elucidating mechanisms underlying growth regulation in development. Investigations usingDrosophilahas yielded new insights into the molecular mechanisms involved in tumor initiation and progression. In this review, we describe various tumor models that have been developed in recent years using differentDrosophilatissues, such as the imaginal tissue, the neural tissue, the gut, the ovary, and hematopoietic cells. We discuss underlying genetic alterations, cancer‐like characteristics, as well as similarities and key differences among these models. We also discuss how disruptions in stem cell division and differentiation result in tumor formation in diverse tissues, and highlight new concepts developed using the fly model to understand context‐dependent tumorigenesis. We further discuss the progress made inDrosophilato explore tumor–host interactions that involve the innate immune response to tumor growth and the cachexia wasting phenotype.

This article is categorized under:

Cancer > Genetics/Genomics/Epigenetics

Cancer > Stem Cells and Development

Cancer > Molecular and Cellular Physiology

 
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NSF-PAR ID:
10360506
Author(s) / Creator(s):
 ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
WIREs Mechanisms of Disease
Volume:
13
Issue:
6
ISSN:
2692-9368
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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