skip to main content


Title: Attitudinal Effects of Stimulus Co-occurrence and Stimulus Relations: Sleep Supports Propositional Learning Via Memory Consolidation

Adaptive behavior requires that organisms learn not only which stimuli tend to co-occur (e.g., whether stimulus A co-occurs with unpleasant stimulus B) but also how co-occurring stimuli are related (e.g., whether A starts or stops B). In a preregistered study ( N = 200 adults), we investigated whether sleep would promote adaptive evaluative choices requiring joint memories for stimulus co-occurrences and stimulus relations. Participants learned about hypothetical pharmaceutical products that either cause or prevent positive or negative health conditions, followed by measures of evaluative choices and explicit memory. After a 12-hr retention interval including either nocturnal sleep or daytime wake, participants completed the same measures a second time. Results showed that sleep strengthened the impact of causal product–condition relations on choices (revealed by multinomial modeling analyses) and enhanced memories for specific stimulus co-occurrences (revealed by memory preservation analyses). The findings suggest that sleep promotes adaptive evaluative choices via offline memory consolidation.

 
more » « less
Award ID(s):
1649900
NSF-PAR ID:
10362313
Author(s) / Creator(s):
 ;  ;  ;  
Publisher / Repository:
SAGE Publications
Date Published:
Journal Name:
Social Psychological and Personality Science
Volume:
14
Issue:
1
ISSN:
1948-5506
Page Range / eLocation ID:
p. 51-59
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. Research suggests that evaluations of an object can be simultaneously influenced by (a) the mere co-occurrence of the object with a pleasant or unpleasant stimulus (e.g., mere co-occurrence of object A and negative event B) and (b) the object’s particular relation to the co-occurring stimulus (e.g., object A starts vs. stops negative event B). Using a multinomial modeling approach to disentangle the two kinds of influences on choice decisions, three experiments investigated whether learners can intentionally control the relative impact of stimulus co-occurrence and stimulus relations. An integrative analysis of the data from the three experiments ( N = 1,154) indicate that incentivized instructions to counteract effects of stimulus co-occurrence by focusing on stimulus relations increased the impact of stimulus relations without affecting the impact of stimulus co-occurrence. Implications for evaluative learning, intentional control, and public policy are discussed. 
    more » « less
  2. Abstract

    Sleep's role in memory consolidation is widely acknowledged, but its role in weakening memories is still debated. Memory weakening is evolutionary beneficial and makes an integral contribution to cognition. We sought evidence on whether sleep-based memory reactivation can facilitate memory suppression. Participants learned pairs of associable words (e.g., DIET–CREAM) and were then exposed to hint words (e.g., DIET) and instructed to either recall (“think”) or suppress (“no-think”) the corresponding target words (e.g., CREAM). As expected, suppression impaired retention when tested immediately after a 90-min nap. To test if reactivation could selectively enhance memory suppression during sleep, we unobtrusively presented one of two sounds conveying suppression instructions during sleep, followed by hint words. Results showed that targeted memory reactivation did not enhance suppression-induced forgetting. Although not predicted, post-hoc analyses revealed that sleep cues strengthened memory, but only for suppressed pairs that were weakly encoded before sleep. The results leave open the question of whether memory suppression can be augmented during sleep, but suggest strategies for future studies manipulating memory suppression during sleep. Additionally, our findings support the notion that sleep reactivation is particularly beneficial for weakly encoded information, which may be prioritized for consolidation.

     
    more » « less
  3. Abstract

    Face memory, including the ability to recall a person’s name, is of major importance in social contexts. Like many other memory functions, it may rely on sleep. We investigated whether targeted memory reactivation during sleep could improve associative and perceptual aspects of face memory. Participants studied 80 face-name pairs, and then a subset of spoken names with associated background music was presented unobtrusively during a daytime nap. This manipulation preferentially improved name recall and face recognition for those reactivated face-name pairs, as modulated by two factors related to sleep quality; memory benefits were positively correlated with the duration of stage N3 sleep (slow-wave sleep) and negatively correlated with measures of sleep disruption. We conclude that (a) reactivation of specific face-name memories during sleep can strengthen these associations and the constituent memories, and that (b) the effectiveness of this reactivation depends on uninterrupted N3 sleep.

     
    more » « less
  4. Abstract

    During spatial exploration, neural circuits in the hippocampus store memories of sequences of sensory events encountered in the environment. When sensory information is absent during ‘offline’ resting periods, brief neuronal population bursts can ‘replay’ sequences of activity that resemble bouts of sensory experience. These sequences can occur in either forward or reverse order, and can even include spatial trajectories that have not been experienced, but are consistent with the topology of the environment. The neural circuit mechanisms underlying this variable and flexible sequence generation are unknown. Here we demonstrate in a recurrent spiking network model of hippocampal area CA3 that experimental constraints on network dynamics such as population sparsity, stimulus selectivity, rhythmicity and spike rate adaptation, as well as associative synaptic connectivity, enable additional emergent properties, including variable offline memory replay. In an online stimulus‐driven state, we observed the emergence of neuronal sequences that swept from representations of past to future stimuli on the timescale of the theta rhythm. In an offline state driven only by noise, the network generated both forward and reverse neuronal sequences, and recapitulated the experimental observation that offline memory replay events tend to include salient locations like the site of a reward. These results demonstrate that biological constraints on the dynamics of recurrent neural circuits are sufficient to enable memories of sensory events stored in the strengths of synaptic connections to be flexibly read out during rest and sleep, which is thought to be important for memory consolidation and planning of future behaviour.image

    Key points

    A recurrent spiking network model of hippocampal area CA3 was optimized to recapitulate experimentally observed network dynamics during simulated spatial exploration.

    During simulated offline rest, the network exhibited the emergent property of generating flexible forward, reverse and mixed direction memory replay events.

    Network perturbations and analysis of model diversity and degeneracy identified associative synaptic connectivity and key features of network dynamics as important for offline sequence generation.

    Network simulations demonstrate that population over‐representation of salient positions like the site of reward results in biased memory replay.

     
    more » « less
  5. null (Ed.)
    Abstract Memory consolidation involves the reactivation of memory traces during sleep. If different memories are reactivated each night, how much do they interfere with one another? We examined whether reactivating multiple memories incurs a cost to sleep-related benefits by contrasting reactivation of multiple memories versus single memories during sleep. First, participants learned the on-screen location of different objects. Each object was part of a semantically coherent group comprised of either one, two, or six items (e.g., six different cats). During sleep, sounds were unobtrusively presented to reactivate memories for half of the groups (e.g., “meow”). Memory benefits for cued versus non-cued items were independent of the number of items in the group, suggesting that reactivation occurs in a simultaneous and promiscuous manner. Intriguingly, sleep spindles and delta-theta power modulations were sensitive to group size, reflecting the extent of previous learning. Our results demonstrate that multiple memories may be consolidated in parallel without compromising each memory’s sleep-related benefit. These findings highlight alternative models for parallel consolidation that should be considered in future studies. 
    more » « less