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Deep brain stimulation (DBS) is a common method of combating pathological conditions associated with Parkinson’s disease, Tourette syndrome, essential tremor, and other disorders, but whose mechanisms are not fully understood. One hypothesis, supported experimentally, is that some symptoms of these disorders are associated with pathological synchronization of neurons in the basal ganglia and thalamus. For this reason, there has been interest in recent years in finding efficient ways to desynchronize neurons that are both fast-acting and low-power. Recent results on coordinated reset and periodically forced oscillators suggest that forming distinct clusters of neurons may prove to be more effective than achieving complete desynchronization, in particular by promoting plasticity effects that might persist after stimulation is turned off. Current proposed methods for achieving clustering frequently require either multiple input sources or precomputing the control signal. We propose here a control strategy for clustering, based on an analysis of the reduced phase model for a set of identical neurons, that allows for real-time, single-input control of a population of neurons with low-amplitude, low total energy signals. After demonstrating its effectiveness on phase models, we apply it to full state models to demonstrate its validity. We also discuss the effects of coupling on the efficacy of the strategy proposed and demonstrate that the clustering can still be accomplished in the presence of weak to moderate electrotonic coupling.
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Control of coupled neural oscillations using near-periodic inputs
Deep brain stimulation (DBS) is a commonly used treatment for medication resistant Parkinson’s disease and is an emerging treatment for other neurological disorders. More recently, phase-specific adaptive DBS (aDBS), whereby the application of stimulation is locked to a particular phase of tremor, has been proposed as a strategy to improve therapeutic efficacy and decrease side effects. In this work, in the context of these phase-specific aDBS strategies, we investigate the dynamical behavior of large populations of coupled neurons in response to near-periodic stimulation, namely, stimulation that is periodic except for a slowly changing amplitude and phase offset that can be used to coordinate the timing of applied input with a specified phase of model oscillations. Using an adaptive phase-amplitude reduction strategy, we illustrate that for a large population of oscillatory neurons, the temporal evolution of the associated phase distribution in response to near-periodic forcing can be captured using a reduced order model with four state variables. Subsequently, we devise and validate a closed-loop control strategy to disrupt synchronization caused by coupling. Additionally, we identify strategies for implementing the proposed control strategy in situations where underlying model equations are unavailable by estimating the necessary terms of the reduced order equations in real-time from observables.
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- Award ID(s):
- 2140527
- PAR ID:
- 10364563
- Publisher / Repository:
- American Institute of Physics
- Date Published:
- Journal Name:
- Chaos: An Interdisciplinary Journal of Nonlinear Science
- Volume:
- 32
- Issue:
- 3
- ISSN:
- 1054-1500
- Page Range / eLocation ID:
- Article No. 033130
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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