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Title: SimSCSnTree: a simulator of single-cell DNA sequencing data
Abstract Summary

We report on a new single-cell DNA sequence simulator, SimSCSnTree, which generates an evolutionary tree of cells and evolves single nucleotide variants (SNVs) and copy number aberrations (CNAs) along its branches. Data generated by the simulator can be used to benchmark tools for single-cell genomic analyses, particularly in cancer where SNVs and CNAs are ubiquitous.

Availability and implementation

SimSCSnTree is now on BioConda and also is freely available for download at https://github.com/compbiofan/SimSCSnTree.git with detailed documentation.

 
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NSF-PAR ID:
10367321
Author(s) / Creator(s):
; ;
Publisher / Repository:
Oxford University Press
Date Published:
Journal Name:
Bioinformatics
Volume:
38
Issue:
10
ISSN:
1367-4803
Format(s):
Medium: X Size: p. 2912-2914
Size(s):
["p. 2912-2914"]
Sponsoring Org:
National Science Foundation
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