The malaria parasite
To evaluate the gene expression response of mosquitoes exposed to a
Differential gene expression analyses showed that during ookinete invasion (24 hpf), genes related to oxidoreductase activity and galactose catabolism had lower expression levels in infected mosquitoes compared to controls. Oocyst development (5 dpf) was associated with reduced expression of a gene with a predicted innate immune function. At 10 dpf, infected mosquitoes had reduced expression levels of a serine protease inhibitor, and further studies should assess its role as a
This is the first analysis of the transcriptional responses of vectors to malaria parasites in non-mammalian systems. Interestingly, few similarities were found between the response of
- NSF-PAR ID:
- 10370326
- Publisher / Repository:
- Springer Science + Business Media
- Date Published:
- Journal Name:
- Malaria Journal
- Volume:
- 21
- Issue:
- 1
- ISSN:
- 1475-2875
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Graphical Abstract
