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Title: PICKLE associates with histone deacetylase 9 to mediate vegetative phase change in Arabidopsis
Summary The juvenile‐to‐adult vegetative phase change in flowering plants is mediated by a decrease in miR156 levels. Downregulation ofMIR156A/MIR156C, the two major sources of miR156, is accompanied by a decrease in acetylation of histone 3 lysine 27 (H3K27ac) and an increase in trimethylation of H3K27 (H3K27me3) atMIR156A/MIR156CinArabidopsis.Here, we show that histone deacetylase 9 (HDA9) is recruited toMIR156A/MIR156Cduring the juvenile phase and associates with the CHD3 chromatin remodeler PICKLE (PKL) to erase H3K27ac atMIR156A/MIR156C.H2Aub and H3K27me3 become enriched atMIR156A/MIR156C, and the recruitment of Polycomb Repressive Complex 2 (PRC2) toMIR156A/MIR156Cis partially dependent on the activities of PKL and HDA9.Our results suggest that PKL associates with histone deacetylases to erase H3K27ac and promote PRC1 and PRC2 activities to mediate vegetative phase change and maintain plants in the adult phase after the phase transition.  more » « less
Award ID(s):
1947274
PAR ID:
10374788
Author(s) / Creator(s):
 ;  ;  ;  
Publisher / Repository:
Wiley-Blackwell
Date Published:
Journal Name:
New Phytologist
Volume:
235
Issue:
3
ISSN:
0028-646X
Page Range / eLocation ID:
p. 1070-1081
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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