As data sharing has become more prevalent, three pillars - archives, standards, and analysis tools - have emerged as critical components in facilitating effective data sharing and collaboration. This paper compares four freely available intracranial neuroelectrophysiology data repositories: Data Archive for the BRAIN Initiative (DABI), Distributed Archives for Neurophysiology Data Integration (DANDI), OpenNeuro, and Brain-CODE. The aim of this review is to describe archives that provide researchers with tools to store, share, and reanalyze both human and non-human neurophysiology data based on criteria that are of interest to the neuroscientific community. The Brain Imaging Data Structure (BIDS) and Neurodata Without Borders (NWB) are utilized by these archives to make data more accessible to researchers by implementing a common standard. As the necessity for integrating large-scale analysis into data repository platforms continues to grow within the neuroscientific community, this article will highlight the various analytical and customizable tools developed within the chosen archives that may advance the field of neuroinformatics.
- Award ID(s):
- 1912266
- PAR ID:
- 10385260
- Date Published:
- Journal Name:
- eLife
- Volume:
- 10
- ISSN:
- 2050-084X
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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This paper reports on a project funded through the Engineering Education and Centers (EEC) Division of the National Science Foundation. Since 2010, EEC has funded more than 500 proposals totaling over $150 million through engineering education research (EER) programs such as Research in Engineering Education (REE) and Research in the Formation of Engineers (RFE), to enhance understanding and improve practice. The resulting archive of robust qualitative and quantitative data represents a vast untapped potential to exponentially increase the impact of EEC funding and transform engineering education. But tapping this potential has thus far been an intractable problem, despite ongoing calls for data sharing by public funders of research. Changing the paradigm of single-use data collection requires actionable, proven practices for effective, ethical data sharing, coupled with sufficient incentives to both share and use existing data. To that end, this project draws together a team of experts to overcome substantial obstacles in qualitative data sharing by building a framework to guide secondary analysis in engineering education research (EER), and to test this framework using pioneering data sets. Herein, we report on accomplishments within the first year of the project during which time we gathered a group of 13 expert qualitative researchers to engage in the first of a series of working meetings intended to meet our project goals. We came into this first workshop with a potentially limiting definition of secondary data analysis and the idea that people would want to share existing datasets if we could find ways around anticipated hurdles. However, the workshop yielded a broader definition of secondary data analysis and revealed a stronger interest in creating new datasets designed for sharing rather than sharing existing datasets. Thus, we have reconceived our second phase as one that is a cohesive effort based on an inclusive “open cohort model” to pilot projects related to secondary data analysis.more » « less
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Purpose A new method for enhancing the sensitivity of diffusion MRI (dMRI) by combining the data from single (sPFG) and double (dPFG) pulsed field gradient experiments is presented.
Methods This method uses our JESTER framework to combine microscopic anisotropy information from dFPG experiments using a new method called diffusion tensor subspace imaging (DiTSI) to augment the macroscopic anisotropy information from sPFG data analyzed using our guided by entropy spectrum pathways method. This new method, called joint estimation diffusion imaging (JEDI), combines the sensitivity to macroscopic diffusion anisotropy of sPFG with the sensitivity to microscopic diffusion anisotropy of dPFG methods.
Results Its ability to produce significantly more detailed anisotropy maps and more complete fiber tracts than existing methods within both brain white matter (WM) and gray matter (GM) is demonstrated on normal human subjects on data collected using a novel fast, robust, and clinically feasible sPFG/dPFG acquisition.
Conclusions The potential utility of this method is suggested by an initial demonstration of its ability to mitigate the problem of gyral bias. The capability of more completely characterizing the tissue structure and connectivity throughout the entire brain has broad implications for the utility and scope of dMRI in a wide range of research and clinical applications.
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.7554/eLife.71774
