Yasur volcano, Vanuatu is a continuously active open-vent basaltic-andesite stratocone with persistent and long-lived eruptive activity. We present results from a seismo-acoustic field experiment at Yasur, providing locally dense broad-band seismic and infrasonic network coverage from 2016 July 27 to August 3. We corroborate our seismo-acoustic observations with coincident video data from cameras deployed at the crater and on an unoccupied aircraft system (UAS). The waveforms contain a profusion of signals reflecting Yasur’s rapidly occurring and persistent explosive activity. The typical infrasonic signature of Yasur explosions is a classic short-duration and often asymmetric explosion waveform characterized by a sharp compressive onset and wideband frequency content. The dominant seismic signals are numerous repetitive very-long-period (VLP) signals with periods of ∼2–10 s. The VLP seismic events are ‘high-rate’, reoccurring near-continuously throughout the data set with short interevent times (∼20–60 s). We observe variability in the synchronization of seismic VLP and acoustic sources. Explosion events clearly delineated by infrasonic waveforms are underlain by seismic VLPs. However, strong seismic VLPs also occur with only a weak infrasonic expression. Multiplet analysis of the seismic VLPs reveals a systematic progression in the seismo-acoustic source decoupling. The same dominant seismic VLP multiplet occurs with and without surficial explosions and infrasound, and these transitions occur over a timescale of a few days during our field campaign. We subsequently employ template matching, stacking, and full-waveform inversion to image the source mechanism of the dominant VLP multiplet. Inversion of the dominant VLP multiplet stack points to a composite source consisting of either a dual-crack (plus forces) or pipe-crack (plus forces) mechanism. The derived mechanisms correspond to a point-source directly beneath the summit vents with centroid depths in the range ∼900–1000 m below topography. All mechanisms suggest a northeast trending crack dipping relatively shallowly to the northwest and indicate a VLP source centroid and mechanism controlled by a stable structural geologic feature beneath Yasur. We interpret the results in the framework of gas slug ascent through the conduit responsible for Yasur explosions. The VLP mechanism and timing with infrasound (when present) are explained by a shallow-buffered top-down model in which slug ascent is relatively aseismic until reaching the base of a shallow section. Slug disruption in this shallow zone triggers a pressure disturbance that propagates downward and couples at the conduit base (VLP centroid). If the shallow section is open, an explosion propagates to the surface, producing infrasound. In the case of (the same multiplet) VLPs occurring without surficial explosions and weak or no infrasound, the decoupling of the dominant VLPs at ∼900–1000 m depth from surficial explosions and infrasound strongly indicates buffering of the terminal slug ascent. This buffering could be achieved by a variety of conditions at or directly beneath the vents, such as a high-viscosity layer of crystal-rich magma, a debris cap from backfill, a foam layer, or a combination of these. The dominant VLP at Yasur captured by our experiment has a source depth and mechanism separated from surface processes and is stable over time.
At Stromboli Volcano, Italy, very long period (VLP) seismic signals and Strombolian eruptions have been attributed to the unsteady flow of gas slugs through the shallow plumbing system followed by explosive slug bursting at a free surface. In data from a 2018 seismo‐acoustic deployment, ∼92% of events in two main VLP multiplets do not coincide in time with impulsive infrasonic signals (the expected signal of explosive slug bursting); we term these “silent VLPs.” The lack of infrasonically detected explosions relative to repeating VLPs does not support the commonly invoked “gas slug” model. We propose that VLPs may be generated when gas bubbles move into a weak semi‐solid plug in the uppermost portion of the conduit. The plug then acts as a mechanical filter in which pathways vary and guide or trap ascending gas slugs, allowing for passive (silent) gas release and explosive escape mechanisms decoupled in time from VLPs.
more » « less- Award ID(s):
- 1901614
- NSF-PAR ID:
- 10386643
- Publisher / Repository:
- DOI PREFIX: 10.1029
- Date Published:
- Journal Name:
- Geophysical Research Letters
- Volume:
- 49
- Issue:
- 23
- ISSN:
- 0094-8276
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Methods In vivo studies were conducted in transgenic mice expressing human ACE2 (K18hACE2), C57BL/6J, and Balb/cJ. Flow cytometry was used to check S-protein expressing pseudo-virus-like particles (VLP) uptake by the lung cells and test the immuogenicity of AYA2012004_L. Ames test was used to assess mutagenicity of AYA2012004_L. RT-PCR and histopathology were used to determine the biodistribution and toxicity of AYA2012004_L in vital organs of mice.
Results We measured the in vivo uptake of VLPs by lung cells by detecting GFP signal using flow cytometry. AYA2012004_L specifically neutralized VLP uptake and also showed no inflammatory response in mice lungs. In addition, AYA2012004_L did not induce inflammatory response in the lungs of Th1 and Th2 mouse models as well as human PBMCs. AYA2012004_L was detectable in mice lungs and noticeable in insignificant amounts in other vital organs. Accumulation of AYA2012004_L in organs decreased over time. AYA2012004_L did not induce degenerative signs in tissues as seen by histopathology and did not cause changes in the body weight of mice. Ames test also certified that AYA2012004_L is non-mutagenic and proved it to be safe for in vivo studies.
Conclusions Our aptamer is safe, effective, and can neutralize the uptake of VLPs by lung cells when administered locally suggesting that it can be used as a potential therapeutic agent for COVID-19 management.
