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  • Nucleic acid paranemic structures: a promising building block for functional nanomaterials in biomedical and bionanotechnological applications
Title: Nucleic acid paranemic structures: a promising building block for functional nanomaterials in biomedical and bionanotechnological applications
Over the past few decades, DNA has been recognized as a powerful self-assembling material capable of crafting supramolecular nanoarchitectures with quasi-angstrom precision, which promises various applications in the fields of materials science, nanoengineering, and biomedical science. Notable structural features include biocompatibility, biodegradability, high digital encodability by Watson–Crick base pairing, nanoscale dimension, and surface addressability. Bottom-up fabrication of complex DNA nanostructures relies on the design of fundamental DNA motifs, including parallel (PX) and antiparallel (AX) crossovers. However, paranemic or PX motifs have not been thoroughly explored for the construction of DNA-based nanostructures compared to AX motifs. In this review, we summarize the developments of PX-based DNA nanostructures, highlight the advantages as well as challenges of PX-based assemblies, and give an overview of the structural and chemical features that lend their utilization in a variety of applications. The works presented cover PX-based DNA nanostructures in biological systems, dynamic systems, and biomedical contexts. The possible future advances of PX structures and applications are also summarized, discussed, and postulated.  more » « less
Award ID(s):
2046835 1905142 2007821
PAR ID:
10388614
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Date Published:
Journal Name:
Journal of Materials Chemistry B
Volume:
10
Issue:
37
ISSN:
2050-750X
Page Range / eLocation ID:
7460 to 7472
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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