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Title: A photochemical C=C cleavage process: toward access to backbone N -formyl peptides
Photo-responsive modifications and photo-uncaging concepts are useful for spatiotemporal control of peptides structure and function. While side chain photo-responsive modifications are relatively common, access to photo-responsive modifications of backbone N–H bonds is quite limited. This letter describes a new photocleavage pathway, affording N -formyl amides from vinylogous nitroaryl precursors under physiologically relevant conditions via a formal oxidative C=C cleavage. The N -formyl amide products have unique properties and reactivity, but are difficult or impossible to access by traditional synthetic approaches.  more » « less
Award ID(s):
1904865
PAR ID:
10390884
Author(s) / Creator(s):
;
Date Published:
Journal Name:
Beilstein Journal of Organic Chemistry
Volume:
17
ISSN:
1860-5397
Page Range / eLocation ID:
2932 to 2938
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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