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Title: ORChestra coordinates the replication and repair music
Abstract

Error‐free genome duplication and accurate cell division are critical for cell survival. In all three domains of life, bacteria, archaea, and eukaryotes, initiator proteins bind replication origins in an ATP‐dependent manner, play critical roles in replisome assembly, and coordinate cell‐cycle regulation. We discuss how the eukaryotic initiator, Origin recognition complex (ORC), coordinates different events during the cell cycle. We propose that ORC is the maestro driving the orchestra to coordinately perform the musical pieces of replication, chromatin organization, and repair.

 
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Award ID(s):
1818286 2225464
NSF-PAR ID:
10398393
Author(s) / Creator(s):
 ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
BioEssays
Volume:
45
Issue:
4
ISSN:
0265-9247
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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