Encapsulation of small molecule drugs in long‐circulating lipid nanoparticles (LNPs) can reduce toxic side effects and enhance accumulation at tumor sites. A fundamental problem, however, is the slow release of encapsulated drugs from these liposomal systems at the disease site resulting in limited therapeutic benefit. Methods to trigger release at specific sites are highly warranted. Here, it is demonstrated that incorporation of ultraviolet (UV‐A) or red‐light photoswitchable‐phosphatidylcholine analogs (AzoPC and redAzoPC) in conventional LNPs generates photoactivatable LNPs (paLNPs) having comparable structural integrity, drug loading capacity, and size distribution to the parent DSPC‐cholesterol liposomes. It is shown that 65–70% drug release (doxorubicin) can be induced from these systems by irradiation with pulsed light based on
- Award ID(s):
- 1554166
- NSF-PAR ID:
- 10405666
- Date Published:
- Journal Name:
- International Journal of Molecular Sciences
- Volume:
- 23
- Issue:
- 19
- ISSN:
- 1422-0067
- Page Range / eLocation ID:
- 11662
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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