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Title: Prevalent use and evolution of exonic regulatory sequences in the human genome
Abstract Key points

There are more exonic regulatory sequences in the human genome than originally thought.

Exonic transcription factor binding sites are more likely under negative selection or positive selection than counterpart nonregulatory sequences.

Exonic transcription factor binding sites tend to be located in genome sequences that encode less critical loops in protein structures, or in less critical parts in 5′ and 3′ untranslated regions.

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Author(s) / Creator(s):
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Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Natural Sciences
Medium: X
Sponsoring Org:
National Science Foundation
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