A stimuli-responsive liposomal platform that is selectively activated by inositol 1,4,5-trisphosphate (IP 3 ) over eleven other phosphorylated metabolites is reported. Dye release assays validated dose-dependent release of both hydrophilic and hydrophobic cargo driven by IP 3 , showcasing the potential of this platform for triggered release and sensing applications.
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Azido Inositol Probes Enable Metabolic Labeling of Inositol-Containing Glycans and Reveal an Inositol Importer in Mycobacteria