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Title: Highlighting the Unique Roles of Radical S -Adenosylmethionine Enzymes in Methanogenic Archaea
ABSTRACT Radical S -adenosylmethionine (SAM) enzymes catalyze an impressive variety of difficult biochemical reactions in various pathways across all domains of life. These metalloenzymes employ a reduced [4Fe-4S] cluster and SAM to generate a highly reactive 5′-deoxyadenosyl radical that is capable of initiating catalysis on otherwise unreactive substrates. Interestingly, the genomes of methanogenic archaea encode many unique radical SAM enzymes with underexplored or completely unknown functions. These organisms are responsible for the yearly production of nearly 1 billion tons of methane, a potent greenhouse gas as well as a valuable energy source. Thus, understanding the details of methanogenic metabolism and elucidating the functions of essential enzymes in these organisms can provide insights into strategies to decrease greenhouse gas emissions as well as inform advances in bioenergy production processes. This minireview provides an overview of the current state of the field regarding the functions of radical SAM enzymes in methanogens and discusses gaps in knowledge that should be addressed.  more » « less
Award ID(s):
2105598
PAR ID:
10411591
Author(s) / Creator(s):
; ;
Editor(s):
Maupin-Furlow, Julie A.
Date Published:
Journal Name:
Journal of Bacteriology
Volume:
204
Issue:
8
ISSN:
0021-9193
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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