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Heating of surface acoustic wave (SAW) devices can be utilized for micro-heating and in microreactor applications, but is a disadvantage in biosensing. In this contribution, we fabricate SAW devices in 128° YX LiNbO3 and ST X quartz substrates with same physical dimensions, having center frequencies approximately of 96 MHz and 78 MHz, respectively to study heating at several power levels. We demonstrate droplet heating is caused by acoustic wave streaming resulting from the coupling between fluid and solid. A 10 μm water droplet on a 128° YX LiNbO3 device can be heated up by 3.3 °C with 15 dbm power level, whereas, the ST X quartz device is only heated up by 0.7°C. Our work illustrates that the 128° YX LiNbO3 substrate shows great potential for liquid heating applications. The ST quartz substrate is better suited for removal of non-specifically bound (NSB) proteins in biosensing applications, especially if shear horizontal SAWs propagating in the orthogonal direction are utilized for biosensing.
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Orthogonal Surface Acoustic Wave (SAW) Sensor for Cancer Biomarker Detection with Accelerated Binding Kinetics
A device incorporating both Rayleigh wave and shear horizontal surface acoustic waves is made on a ST-Quartz substrate. The Rayleigh wave induced microfluidic mixing shows effects on accelerating the binding kinetics of real-time sensing between antibody and antigen, which is measured by phase change from the shear horizontal surface acoustic wave direction on the ST-Quartz. Preliminary results on this device show shortened response time and enhanced phase signal when the binding is accelerated by microfluidic streaming from the Rayleigh wave. The device can be fabricated using a low cost, single step photolithography method and can be combined with a small electronic sensor for data readout, which allows for a variety of surface-based biomarker detections on a portable platform. In this work, detection of Carcinoembryonic antigen (CEA) binding with functionalized capture antibody is studied to show the effects of mass loading amplification due to Rayleigh wave microfluidic streaming.
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- Award ID(s):
- 2108795
- PAR ID:
- 10414781
- Date Published:
- Journal Name:
- 2022 IEEE Sensors
- Page Range / eLocation ID:
- 1 to 3
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Conference Paper:
- https://doi.org/10.1109/SENSORS52175.2022.9967354
