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Title: Photolabile Protecting Groups Based on the Excited State Meta Effect: Development and Application †
Abstract

This review focuses on utilization of the excited statemetaeffect (ESME) in the development of photolabile protecting groups (PPGs). Structurally simple ESME‐based PPGs for release of various functional groups (such as carbonyl, hydroxyl, carboxyl, amino and thiol groups) are discussed. Examples that demonstrate the appealing advantages of these new PPGs are provided, including their efficient release of “poor” leaving groups such as hydroxyl or amino group directly instead of in their respective carbonate or carbamate form. Applications of these PPGs in synthesis, release of biologically important molecules, materials science and biomedical engineering are also described.

 
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PAR ID:
10420689
Author(s) / Creator(s):
 ;  
Publisher / Repository:
Wiley-Blackwell
Date Published:
Journal Name:
Photochemistry and Photobiology
Volume:
99
Issue:
2
ISSN:
0031-8655
Page Range / eLocation ID:
p. 221-234
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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