Biofilms are aggregates of bacterial cells surrounded by an extracellular matrix. Much progress has been made in studying biofilm growth on solid substrates; however, little is known about the biophysical mechanisms underlying biofilm development in three-dimensional confined environments in which the biofilm-dwelling cells must push against and even damage the surrounding environment to proliferate. Here, combining single-cell imaging, mutagenesis, and rheological measurement, we reveal the key morphogenesis steps of
- PAR ID:
- 10427878
- Editor(s):
- Balaban, Nathalie
- Date Published:
- Journal Name:
- PLOS Biology
- Volume:
- 20
- Issue:
- 10
- ISSN:
- 1545-7885
- Page Range / eLocation ID:
- e3001846
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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