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Title: Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
Award ID(s):
2145491
NSF-PAR ID:
10436330
Author(s) / Creator(s):
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Date Published:
Journal Name:
Journal of the American Chemical Society
Volume:
145
Issue:
8
ISSN:
0002-7863
Page Range / eLocation ID:
4691 to 4706
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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  1. SUMMARY

    The seismic quality factor (Q) of the Earth’s mantle is of great importance for the understanding of the physical and chemical properties that control mantle anelasticity. The radial structure of the Earth’s Q is less well resolved compared to its wave speed structure, and large discrepancies exist among global 1-D Q models. In this study, we build a global data set of amplitude measurements of S, SS, SSS and SSSS waves using earthquakes that occurred between 2009 and 2017 with moment magnitudes ranging from 6.5 to 8.0. Synthetic seismograms for those events are computed in a 1-D reference model PREM, and amplitude ratios between observed and synthetic seismograms are calculated in the frequency domain by spectra division, with measurement windows determined based on visual inspection of seismograms. We simulate wave propagation in a global velocity model S40RTS based on SPECFEM3D and show that the average amplitude ratio as a function of epicentral distance is not sensitive to 3-D focusing and defocusing for the source–receiver configuration of the data set. This data set includes about 5500 S and SS measurements that are not affected by mantle transition zone triplications (multiple ray paths), and those measurements are applied in linear inversions to obtain a preliminary 1-D Q model QMSI. This model reveals a high Q region in the uppermost lower mantle. While model QMSI improves the overall datafit of the entire data set, it does not fully explain SS amplitudes at short epicentral distances or the amplitudes of the SSS and SSSS waves. Using forward modelling, we modify the 1-D model QMSI iteratively to reduce the overall amplitude misfit of the entire data set. The final Q model QMSF requires a stronger and thicker high Q region at depths between 600 and 900 km. This anelastic structure indicates possible viscosity layering in the mid mantle.

     
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  2. null (Ed.)