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1. Evaluating Unsupervised Denoising Requires Unsupervised Metrics

   Morales, Adria Marcos ; Leibovich, Matan ; Mohan, Sreyas ; Vincent, Joshua Lawrence ; Haluai, Piyush ; Tan, Mai ; Crozier, Peter ; Fernandez-Granda, Carlos ( June 2023 , Proceedings of the 40th International Conference on Machine Learning (ICML), PMLR)

   Unsupervised denoising is a crucial challenge in real-world imaging applications. Unsupervised deep-learning methods have demonstrated impressive performance on benchmarks based on synthetic noise. However, no metrics are available to evaluate these methods in an unsupervised fashion. This is highly problematic for the many practical applications where ground-truth clean images are not available. In this work, we propose two novel metrics: the unsupervised mean squared error (MSE) and the unsupervised peak signal-to-noise ratio (PSNR), which are computed using only noisy data. We provide a theoretical analysis of these metrics, showing that they are asymptotically consistent estimators of the supervised MSE and PSNR. Controlled numerical experiments with synthetic noise confirm that they provide accurate approximations in practice. We validate our approach on real-world data from two imaging modalities: videos in raw format and transmission electron microscopy. Our results demonstrate that the proposed metrics enable unsupervised evaluation of denoising methods based exclusively on noisy data. 

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2. Evaluating Unsupervised Denoising Requires Unsupervised Metrics

   Marcos-Morales, Adria ; Leibovich, Matan ; Mohan, Sreyas ; Vincent, Joshua Lawrence ; Haluai, Piyush ; Tan, Mai ; Crozier, Peter ; Fernandez-Granda, Carlos ( August 2023 , Proceedings of the 40th International Conference on Machine Learning (ICML), PMLR)

   Unsupervised denoising is a crucial challenge in real-world imaging applications. Unsupervised deep-learning methods have demonstrated impressive performance on benchmarks based on synthetic noise. However, no metrics exist to evaluate these methods in an unsupervised fashion. This is highly problematic for the many practical applications where ground-truth clean images are not available. In this work, we propose two novel metrics: the unsupervised mean squared error (MSE) and the unsupervised peak signalto-noise ratio (PSNR), which are computed using only noisy data. We provide a theoretical analysis of these metrics, showing that they are asymptotically consistent estimators of the supervised MSE and PSNR. Controlled numerical experiments with synthetic noise confirm that they provide accurate approximations in practice. We validate our approach on real-world data from two imaging modalities: videos in raw format and transmission electron microscopy. Our results demonstrate that the proposed metrics enable unsupervised evaluation of denoising methods based exclusively on noisy data. 

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3. Unsupervised Deep Video Denoising

   Sheth, Dev Yashpal ; Mohan, Sreyas ; Vincent, Joshua L. ; Manzorro, Ramon ; Crozier, Peter A. ; Khapra, Mitesh M. ; Simoncelli, Eero P. ; Fernandez-Granda, Carlos ( December 2020 , ArXivorg)

   null (Ed.)

   Deep convolutional neural networks (CNNs) for video denoising are typically trained with supervision, assuming the availability of clean videos. However, in many applications, such as microscopy, noiseless videos are not available. To address this, we propose an Unsupervised Deep Video Denoiser (UDVD1), a CNN architecture designed to be trained exclusively with noisy data. The performance of UDVD is comparable to the supervised state-of-the-art, even when trained only on a single short noisy video. We demonstrate the promise of our approach in real-world imaging applications by denoising raw video, fluorescencemicroscopy and electron-microscopy data. In contrast to many current approaches to video denoising, UDVD does not require explicit motion compensation. This is advantageous because motion compensation is computationally expensive, and can be unreliable when the input data are noisy. A gradient-based analysis reveals that UDVD automatically adapts to local motion in the input noisy videos. Thus, the network learns to perform implicit motion compensation, even though it is only trained for denoising. 

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4. Deep Denoising for Scientific Discovery: A Case Study in Electron Microscopy

   Mohan, Sreyas ; Manzorro, Ramon ; Vincent, Joshua L. ; Tang, Binh ; Sheth, Dev Y. ; Simoncelli, Eero P. ; Matteson, David S. ; Crozier, Peter A. ; Fernandez-Granda, Carlos ( March 2021 , ArXivorg)

   null (Ed.)

   Denoising is a fundamental challenge in scientific imaging. Deep convolutional neural networks (CNNs) provide the current state of the art in denoising natural images, where they produce impressive results. However, their potential has been inadequately explored in the context of scientific imaging. Denoising CNNs are typically trained on real natural images artificially corrupted with simulated noise. In contrast, in scientific applications, noiseless ground-truth images are usually not available. To address this issue, we propose a simulation-based denoising (SBD) framework, in which CNNs are trained on simulated images. We test the framework on data obtained from transmission electron microscopy (TEM), an imaging technique with widespread applications in material science, biology, and medicine. SBD outperforms existing techniques by a wide margin on a simulated benchmark dataset, as well as on real data. We analyze the generalization capability of SBD, demonstrating that the trained networks are robust to variations of imaging parameters and of the underlying signal structure. Our results reveal that state-of-the-art architectures for denoising photographic images may not be well adapted to scientific-imaging data. For instance, substantially increasing their field-of-view dramatically improves their performance on TEM images acquired at low signal-to-noise ratios. We also demonstrate that standard performance metrics for photographs (such as PSNR and SSIM) may fail to produce scientifically meaningful evaluation. We propose several metrics to remedy this issue for the case of atomic resolution electron microscope images. In addition, we propose a technique, based on likelihood computations, to visualize the agreement between the structure of the denoised images and the observed data. Finally, we release a publicly available benchmark dataset of TEM images, containing 18,000 examples. 

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5. Learning with Noisy Labels Revisited: A Study Using Real-World Human Annotations

   Wei, Jiaheng ; Zhu, Zhaowei ; Cheng, Hao ; Liu, Tongliang ; Niu, Gang ; Liu, Yang ( January 2022 , International Conference on Learning Representations)

   Existing research on learning with noisy labels mainly focuses on synthetic label noise. Synthetic label noise, though has clean structures which greatly enable statistical analyses, often fails to model the real-world noise patterns. The recent literature has observed several efforts to offer real-world noisy datasets, e.g., Food-101N, WebVision, and Clothing1M. Yet the existing efforts suffer from two caveats: firstly, the lack of ground-truth verification makes it hard to theoretically study the property and treatment of real-world label noise. Secondly, these efforts are often of large scales, which may result in unfair comparisons of robust methods within reasonable and accessible computation power. To better understand real-world label noise, it is important to establish controllable and moderate-sized real-world noisy datasets with both ground-truth and noisy labels. This work presents two new benchmark datasets, which we name as CIFAR-10N, CIFAR-100N, equipping the training datasets of CIFAR-10 and CIFAR-100 with human-annotated real-world noisy labels that we collect from Amazon Mechanical Turk. We quantitatively and qualitatively show that real-world noisy labels follow an instance-dependent pattern rather than the classically assumed and adopted ones (e.g., class-dependent label noise). We then initiate an effort to benchmark a subset of the existing solutions using CIFAR-10N and CIFAR-100N. We further proceed to study the memorization of correct and wrong predictions, which further illustrates the difference between human noise and class-dependent synthetic noise. We show indeed the real-world noise patterns impose new and outstanding challenges as compared to synthetic label noise. These observations require us to rethink the treatment of noisy labels, and we hope the availability of these two datasets would facilitate the development and evaluation of future learning with noisy label solutions. The corresponding datasets and the leaderboard are publicly available at http://noisylabels.com. 

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