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Title: Enantioselective Fluorescent Recognition of β‐Amino Alcohols by Stereoselective Cyclization

2,2’‐Diformyl‐1,1’‐binaphthyl is found to exhibit highly enantioselective fluorescence enhancement in the presence of various β‐amino alcohols and base. It provides a new method to determine the enantiomeric composition of those substrates and has potential for high throughput analysis. Based on detailed spectroscopic analyses, it is proposed that a stereoselective cyclization of a β‐amino alcohol with the probe should occur to form a rigid macrocyclic intermediate, contributing to the greatly enhanced fluorescence.

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Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
European Journal of Organic Chemistry
Medium: X
Sponsoring Org:
National Science Foundation
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