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Title: Network and cellular mechanisms underlying heterogeneous excitatory/inhibitory balanced states

Recent work has explored spatiotemporal relationships between excitatory (E) and inhibitory (I) signaling within neural networks, and the effect of these relationships on network activity patterns. Data from these studies have indicated that excitation and inhibition are maintained at a similar level across long time periods and that excitatory and inhibitory currents may be tightly synchronized. Disruption of this balance—leading to an aberrantE/Iratio—is implicated in various brain pathologies. However, a thorough characterization of the relationship betweenEandIcurrents in experimental settings is largely impossible, due to their tight regulation at multiple cellular and network levels. Here, we use biophysical neural network models to investigate the emergence and properties of balanced states by heterogeneous mechanisms. Our results show that a network can homeostatically regulate theE/Iratio through interactions among multiple cellular and network factors, including average firing rates, synaptic weights and average neural depolarization levels in excitatory/inhibitory populations. Complex and competing interactions between firing rates and depolarization levels allow these factors to alternately dominate network dynamics in different synaptic weight regimes. This leads to the emergence of distinct mechanisms responsible for determining a balanced state and its dynamical correlate. Our analysis provides a comprehensive picture of howE/Iratio changes when manipulating specific network properties, and identifies the mechanisms regulatingE/Ibalance. These results provide a framework to explain the diverse, and in some cases, contradictory experimental observations on theE/Istate in different brain states and conditions.

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Author(s) / Creator(s):
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Publisher / Repository:
Date Published:
Journal Name:
European Journal of Neuroscience
Page Range / eLocation ID:
p. 1624-1641
Medium: X
Sponsoring Org:
National Science Foundation
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