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Abstract The convergence of nanotechnology and bioprinting is redefining the landscape of tissue engineering, with nanocomposite gelatin methacryloyl (GelMA) bioinks emerging as a transformative platform for the biofabrication of multifunctional tissue‐specific constructs. GelMA, a photocrosslinkable hydrogel, has rapidly gained attention due to its intrinsic bioactivity, tunable mechanical properties, and compatibility with living cells. However, despite its wide applicability regenerating muscle, cartilage, bone, vascular, cardiac, and neural tissues, native GelMA suffers from limited mechanical strength and insufficient biofunctionality to recapitulate the complexity of specialized tissues. To overcome these shortcomings, recent strategies have focused on the incorporation of nanomaterials into GelMA matrices, ranging from inorganic and carbon‐based to metallic, polymeric, and lipidic nanomaterials. These nanocomposite bioprinted scaffolds impart critical enhancements, including improved mechanical robustness, electrical conductivity, stimuli‐responsiveness, and bioactivity, while also enabling advanced functionalities such as controlled drug release and real‐time responsiveness to the cellular microenvironment. This review examines the bioprinting parameters, material synergies, and design strategies governing the performance of nanocomposite GelMA bioinks. By integrating the tunability of photocrosslinkable bioinks with the multifunctionality of nanomaterials, nanocomposite GelMA bioinks represent a next‐generation platform capable of addressing the complex demands of tissue repair and regeneration.
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Bone Tissue Engineering via Carbon‐Based Nanomaterials
Abstract Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.
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- Award ID(s):
- 1809060
- PAR ID:
- 10457864
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Advanced Healthcare Materials
- Volume:
- 9
- Issue:
- 5
- ISSN:
- 2192-2640
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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