Phagocytosis, macropinocytosis and antigen presentation by dendritic cells (
B‐cell responses are dynamic processes that depend on multiple types of interactions. Rare antigen‐specific B cells must encounter antigen and specialized systems are needed—unique to each lymphoid tissue type—to ensure this happens efficiently. Lymphoid tissue barrier cells act to ensure that pathogens, while being permitted entry for B‐cell recognition, are blocked from replication or dissemination. T follicular helper (Tfh) cells often need to be primed by dendritic cells before supporting B‐cell responses. For most responses, antigen‐specific helper T cells and B cells need to interact, first to initiate clonal expansion and the plasmablast response, and later to support the germinal center (
- PAR ID:
- 10461446
- Publisher / Repository:
- Wiley-Blackwell
- Date Published:
- Journal Name:
- Immunological Reviews
- Volume:
- 289
- Issue:
- 1
- ISSN:
- 0105-2896
- Page Range / eLocation ID:
- p. 158-172
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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