Diverse T and B cell repertoires play an important role in mounting effective immune responses against a wide range of pathogens and malignant cells. The number of unique T and B cell clones is characterized by T and B cell receptors (TCRs and BCRs), respectively. Although receptor sequences are generated probabilistically by recombination processes, clinical studies found a high degree of sharing of TCRs and BCRs among different individuals. In this work, we use a general probabilistic model for T/B cell receptor clone abundances to define “publicness” or “privateness” and information-theoretic measures for comparing the frequency of sampled sequences observed across different individuals. We derive mathematical formulae to quantify the mean
- PAR ID:
- 10462844
- Publisher / Repository:
- Springer Science + Business Media
- Date Published:
- Journal Name:
- Bulletin of Mathematical Biology
- Volume:
- 85
- Issue:
- 10
- ISSN:
- 0092-8240
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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