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Title: Development of the intestinal microbiome in cystic fibrosis in early life
Cystic fibrosis is a heritable disease that disrupts ion transport at mucosal surfaces, causing a buildup of mucus and dysregulation of microbial communities in both the lungs and the intestines. Persons with CF are known to have dysbiotic gut microbial communities, but the development of these communities over time beginning at birth has not been thoroughly studied. Here, we describe an observation study following the development of the gut microbiome of cwCF throughout the first 4 years of life, during the critical window of both gut microbiome and immune development. Our findings indicate the possibility of the gut microbiota as a reservoir of airway pathogens and a surprisingly early indication of a microbiota associated with inflammatory bowel disease.  more » « less
Award ID(s):
2125733
PAR ID:
10464415
Author(s) / Creator(s):
; ; ; ; ; ;
Editor(s):
Young, Vincent B.
Date Published:
Journal Name:
mSphere
Volume:
8
Issue:
4
ISSN:
2379-5042
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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