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1. An individual's skin stiffness predicts their tactile discrimination of compliance

   https://doi.org/10.1113/JP285271  

   Li, Bingxu; Gerling, Gregory J. (November 2023, The Journal of Physiology)

   AbstractIndividual differences in tactile acuity have been correlated with age, gender and finger size, whereas the role of the skin's stiffness has been underexplored. Using an approach to image the 3‐D deformation of the skin surface during contact with transparent elastic objects, we evaluate a cohort of 40 young participants, who present a diverse range of finger size, skin stiffness and fingerprint ridge breadth. The results indicate that skin stiffness generally correlates with finger size, although individuals with relatively softer skin can better discriminate compliant objects. Analysis of contact at the skin surface reveals that softer skin generates more prominent patterns of deformation, in particular greater rates of change in contact area, which correlate with higher rates of perceptual discrimination of compliance, regardless of finger size. Moreover, upon applying hyaluronic acid to soften individuals’ skin, we observe immediate, marked and systematic changes in skin deformation and consequent improvements in perceptual acuity in differentiating compliance. Together, the combination of 3‐D imaging of the skin surface, biomechanics measurements, multivariate regression and clustering, and psychophysical experiments show that subtle distinctions in skin stiffness modulate the mechanical signalling of touch and shape individual differences in perceptual acuity.Key pointsAlthough declines in tactile acuity with ageing are a function of multiple factors, for younger people, the current working hypothesis has been that smaller fingers are better at informing perceptual discrimination because of a higher density of neural afferents.To decouple relative impacts on tactile acuity of skin properties of finger size, skin stiffness, and fingerprint ridge breadth, we combined 3‐D imaging of skin surface deformation, biomechanical measurements, multivariate regression and clustering, and psychophysics.The results indicate that skin stiffness generally correlates with finger size, although it more robustly correlates with and predicts an individual's perceptual acuity.In particular, more elastic skin generates higher rates of deformation, which correlate with perceptual discrimination, shown most dramatically by softening each participant's skin with hyaluronic acid.In refining the current working hypothesis, we show the skin's stiffness strongly shapes the signalling of touch and modulates individual differences in perceptual acuity. 

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2. Individual differences impacting skin deformation and tactile discrimination with compliant elastic surfaces

   https://doi.org/10.1109/WHC49131.2021.9517222  

   Li, Bingxu; Gerling, Gregory J. (July 2021, IEEE World Haptics Conference)

   Individual differences in tactile acuity are observed within and between age cohorts. Such differences in acuity may be attributed to various sources, including aspects of nervous system, skin mechanics, finger size, cognitive and behavioral factors, etc. This work considers individual differences, within a younger cohort of participants, in discriminating compliant surfaces. These participants exhibit a range of finger size and stiffness. Interestingly, both their finger size and stiffness well predict their discriminative performance, where softer/smaller fingers outperform stiffer/larger fingers. Stereo imaging captured biomechanical cues in the skin’s deformation, including contact area and penetration depth, and their change rates. In those individuals with stiffer/larger fingers, who perceptually performed worse, we observed less distinguishable contact areas and eccentricities, compared to softer/smaller fingers. These particular cues well predicted individual differences observed in perceptual discrimination. In comparison, with two other cues, curvature and penetration depth, the imaging readily distinguished the compliant surfaces irrespective of finger stiffness/size, not aligned with discrimination. In conclusion, in passive touch, we find that individuals with softer/smaller fingers were better at discriminating compliances, and that certain skin deformation cues predict individual differences in perception. 

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3. Quantification of age-related changes in the structure and mechanical function of skin with multiscale imaging

   https://doi.org/10.1007/s11357-024-01199-9  

   Woessner, Alan_E; Witt, Nathan_J; Jones, Jake_D; Sander, Edward_A; Quinn, Kyle_P (May 2024, GeroScience)

   Abstract The mechanical properties of skin change during aging but the relationships between structure and mechanical function remain poorly understood. Previous work has shown that young skin exhibits a substantial decrease in tissue volume, a large macro-scale Poisson’s ratio, and an increase in micro-scale collagen fiber alignment during mechanical stretch. In this study, label-free multiphoton microscopy was used to quantify how the microstructure and fiber kinematics of aged mouse skin affect its mechanical function. In an unloaded state, aged skin was found to have less collagen alignment and more non-enzymatic collagen fiber crosslinks. Skin samples were then loaded in uniaxial tension and aged skin exhibited a lower mechanical stiffness compared to young skin. Aged tissue also demonstrated less volume reduction and a lower macro-scale Poisson’s ratio at 10% uniaxial strain, but not at 20% strain. The magnitude of 3D fiber realignment in the direction of loading was not different between age groups, and the amount of realignment in young and aged skin was less than expected based on theoretical fiber kinematics affine to the local deformation. These findings provide key insights on how the collagen fiber microstructure changes with age, and how those changes affect the mechanical function of skin, findings which may help guide wound healing or anti-aging treatments. 

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4. Identifying 3-D spatiotemporal skin deformation cues evoked in interacting with compliant elastic surfaces

   https://doi.org/10.1109/HAPTICS45997.2020.ras.HAP20.22.5a9b38d8  

   Li, Bingxu; Hauser, Steven; Gerling, Gregory J. (March 2020, 2020 IEEE Haptics Symposium (HAPTICS))

   We regularly touch soft, compliant fruits and tissues. To help us discriminate them, we rely upon cues embedded in spatial and temporal deformation of finger pad skin. However, we do not yet understand, in touching objects of various compliance, how such patterns evolve over time, and drive perception. Using a 3-D stereo imaging technique in passive touch, we develop metrics for quantifying skin deformation, across compliance, displacement, and time. The metrics map 2D estimates of terminal contact area to 3-D metrics that represent spatial and temporal changes in penetration depth, surface curvature, and force. To do this, clouds of thousands of 3-D points are reduced in dimensionality into stacks of ellipses, to be more readily comparable between participants and trials. To evaluate the robustness of the derived 3-D metrics, human subjects experiments are performed with stimulus pairs varying in compliance and discriminability. The results indicate that metrics such as penetration depth and surface curvature can distinguish compliances earlier, at less displacement. Observed also are distinct modes of skin deformation, for contact with stiffer objects, versus softer objects that approach the skin's compliance. These observations of the skin's deformation may guide the design and control of haptic actuation. 

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5. Individual Performance in Compliance Discrimination is Constrained by Skin Mechanics but Improved under Active Control

   https://doi.org/10.1109/WHC49131.2021.9517269  

   Xu, Chang; Wang, Yuxiang; Gerling, Gregory J. (July 2021, IEEE World Haptics Conference)

   Tactile acuity differs between individuals, likely a function of several interrelated factors. The extent of the impact of skin mechanics on individual differences is unclear. Herein, we investigate if differences in skin elasticity between individuals impact their ability to distinguish compliant spheres near limits of discriminability. After characterizing hyperelastic material properties of their skin in compression, the participants were asked to discriminate spheres varying in elasticity and curvature, which generate non-distinct cutaneous cues. Simultaneous biomechanical measurements were used to dissociate the relative contributions from skin mechanics and volitional movements in modulating individuals’ tactile sensitivity. The results indicate that, in passive touch, individuals with softer skin exhibit larger gross contact areas and higher perceptual acuity. In contrast, in active touch, where exploratory movements are behaviorally controlled, individuals with harder skin evoke relatively larger gross contact areas, which improve and compensate for deficits in their acuity as observed in passive touch. Indeed, these participants exhibit active control of their fingertip movements that improves their acuity, amidst the inherent constraints of their less elastic finger pad skin. 

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