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Title: A CIE change in our understanding of endocytic mechanisms
The past six decades have seen major advances in our understanding of endocytosis, ranging from descriptive studies based on electron microscopy to biochemical and genetic characterization of factors required for vesicle formation. Most studies focus on clathrin as the major coat protein; indeed, clathrin-mediated endocytosis (CME) is the primary pathway for internalization. Clathrin-independent (CIE) pathways also exist, although mechanistic understanding of these pathways remains comparatively elusive. Here, we discuss how early studies of CME shaped our understanding of endocytosis and describe recent advances in CIE, including pathways in model organisms that are poised to provide key insights into endocytic regulation.  more » « less
Award ID(s):
1942395
PAR ID:
10479439
Author(s) / Creator(s):
;
Editor(s):
Tagaya, Mitsuo
Publisher / Repository:
Frontiers Media
Date Published:
Journal Name:
Frontiers in Cell and Developmental Biology
Volume:
11
ISSN:
2296-634X
Subject(s) / Keyword(s):
endocytosis clathrin-independent clathrin model organism actin small GTPase
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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