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Title: Alcohol-alcohol cross-coupling enabled by S H 2 radical sorting

Alcohols represent a functional group class with unparalleled abundance and structural diversity. In an era of chemical synthesis that prioritizes reducing time to target and maximizing exploration of chemical space, harnessing these building blocks for carbon-carbon bond-forming reactions is a key goal in organic chemistry. In particular, leveraging a single activation mode to form a new C(sp3)–C(sp3) bond from two alcohol subunits would enable access to an extraordinary level of structural diversity. In this work, we report a nickel radical sorting–mediated cross-alcohol coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to air.

 
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Award ID(s):
2316541
PAR ID:
10502926
Author(s) / Creator(s):
; ; ; ; ; ; ;
Editor(s):
Yeston, Jake S.
Publisher / Repository:
American Association for the Advancement of Science
Date Published:
Journal Name:
Science
Volume:
383
Issue:
6689
ISSN:
0036-8075
Page Range / eLocation ID:
1350 to 1357
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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