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This content will become publicly available on January 2, 2025

Title: Salicylic acid in plant immunity and beyond
Abstract

As the most widely used herbal medicine in human history and a major defence hormone in plants against a broad spectrum of pathogens and abiotic stresses, salicylic acid (SA) has attracted major research interest. With applications of modern technologies over the past 30 years, studies of the effects of SA on plant growth, development, and defence have revealed many new research frontiers and continue to deliver surprises. In this review, we provide an update on recent advances in our understanding of SA metabolism, perception, and signal transduction mechanisms in plant immunity. An overarching theme emerges that SA executes its many functions through intricate regulation at multiple steps: SA biosynthesis is regulated both locally and systemically, while its perception occurs through multiple cellular targets, including metabolic enzymes, redox regulators, transcription cofactors, and, most recently, an RNA-binding protein. Moreover, SA orchestrates a complex series of post-translational modifications of downstream signaling components and promotes the formation of biomolecular condensates that function as cellular signalling hubs. SA also impacts wider cellular functions through crosstalk with other plant hormones. Looking into the future, we propose new areas for exploration of SA functions, which will undoubtedly uncover more surprises for many years to come.

 
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Award ID(s):
2041378
NSF-PAR ID:
10503886
Author(s) / Creator(s):
;
Publisher / Repository:
American Society of Plant Biologists
Date Published:
Journal Name:
The Plant Cell
Volume:
36
Issue:
5
ISSN:
1040-4651
Page Range / eLocation ID:
1451 to 1464
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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