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  • Frontiers in mass spectrometry-based spatial metabolomics: Current applications and challenges in the context of biomedical research
Title: Frontiers in mass spectrometry-based spatial metabolomics: Current applications and challenges in the context of biomedical research
Metabolites are critical products and mediators of cellular and tissue function, and key signals in cell-to-cell, organ-to-organ and cross-organism communication. Many of these interactions are spatially segregated. Thus, spatial metabolomics can provide valuable insight into healthy tissue function and disease pathogenesis. Here, we review major mass spectrometry-based spatial metabolomics techniques and the biological insights they have enabled, with a focus on brain and microbiota function and on cancer, neurological diseases and infectious diseases. These techniques also present significant translational utility, for example in cancer diagnosis, and for drug development. However, spatial mass spectrometry techniques still encounter significant challenges, including artifactual features, metabolite annotation, open data, and ethical considerations. Addressing these issues represent the future challenges in this field.  more » « less
Award ID(s):
2305182
PAR ID:
10514909
Author(s) / Creator(s):
; ; ; ;
Publisher / Repository:
Elsevier
Date Published:
Journal Name:
TrAC Trends in Analytical Chemistry
Volume:
175
Issue:
C
ISSN:
0165-9936
Page Range / eLocation ID:
117713
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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