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Title: Biophysical and Integrative Characterization of Protein Intrinsic Disorder as a Prime Target for Drug Discovery
Protein intrinsic disorder is increasingly recognized for its biological and disease-driven functions. However, it represents significant challenges for biophysical studies due to its high conformational flexibility. In addressing these challenges, we highlight the complementary and distinct capabilities of a range of experimental and computational methods and further describe integrative strategies available for combining these techniques. Integrative biophysics methods provide valuable insights into the sequence–structure–function relationship of disordered proteins, setting the stage for protein intrinsic disorder to become a promising target for drug discovery. Finally, we briefly summarize recent advances in the development of new small molecule inhibitors targeting the disordered N-terminal domains of three vital transcription factors.  more » « less
Award ID(s):
2015030
PAR ID:
10521574
Author(s) / Creator(s):
; ; ;
Publisher / Repository:
MDPI
Date Published:
Journal Name:
Biomolecules
Volume:
13
Issue:
3
ISSN:
2218-273X
Page Range / eLocation ID:
530
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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