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Title: A Modular Variable Temperature FT-IMS Instrument Optimized for Gas-Phase Ion Chemistry Applications
The latest iteration of modular, open-source rolled ion mobility spectrometers was characterized and tailored for heated ion chemistry experiments. Because the nature of ion-neutral interactions is innately linked to the temperature of the drift cell, heated IMS experiments explicitly probe the fundamental characteristics of these collisions. While classic mobility experiments examine ions through inert buffer gasses, doping the drift cell with reactive vapor enables desolvated chemical reactions to be studied. By using materials with minimal outgassing and ensuring the isolation of the drift tube from the surrounding ambient conditions, an open-source drift cell outfitted with heating components enables investigations of chemical reactions as a function of temperature. We show here that elevated temperatures facilitate an increase in deuterium incorporation and allow for hydrogen/deuterium exchanges otherwise unattainable under ambient conditions. While the initial fast exchanges get faster as temperature is increased, the slow rate which rises from the kinetic nonlinearity though to be attributed to ion-neutral clustering, remains constant with no change in mobility shifts. Additionally, we show the analytical merit of multiplexing mobility data by comparing the performance of traditional signal-averaging and FT-IMS modes.  more » « less
Award ID(s):
2003042
PAR ID:
10528828
Author(s) / Creator(s):
; ; ;
Publisher / Repository:
Journal of the American Society for Mass Spectrometry
Date Published:
Journal Name:
Journal of the American Society for Mass Spectrometry
ISSN:
1044-0305
Subject(s) / Keyword(s):
Ion mobility spectrometry hydrogen-deuterium exchange ion chemistry
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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