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  • HDXBoxeR: An R package for statistical analysis and visualization of multiple Hydrogen-Deuterium Exchange Mass-Spectrometry datasets of different protein states
Title: HDXBoxeR: An R package for statistical analysis and visualization of multiple Hydrogen-Deuterium Exchange Mass-Spectrometry datasets of different protein states
Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) is a powerful protein characterization technique that provides insights into protein dynamics and flexibility at the peptide level. However, analyzing HDX-MS data presents a significant challenge due to the wealth of information it generates. Each experiment produces data for hundreds of peptides, often measured in triplicate across multiple time points. Comparisons between different protein states create distinct datasets containing thousands of peptides that require matching, rigorous statistical evaluation, and visualization. Our open-source R package, HDXBoxeR, is a comprehensive tool designed to facilitate statistical analysis and comparison of multiple sets among samples and time points for different protein states, along with data visualization.  more » « less
Award ID(s):
2304707
PAR ID:
10528993
Author(s) / Creator(s):
; ; ; ;
Editor(s):
Elofsson, Arne
Publisher / Repository:
Oxford Academic
Date Published:
Journal Name:
Bioinformatics
ISSN:
1367-4811
Subject(s) / Keyword(s):
HDX-MS robot plots analysis deuterium structural analysis
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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