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Title: Towards single cell encapsulation for precision biology and medicine
The primary impetus of therapeutic cell encapsulation in the past several decades has been to broaden the options for donor cell sources by countering against immune-mediated rejection. However, another significant advantage of encapsulation is to provide donor cells with physiologically relevant cues that become compromised in disease. The advances in biomaterial design have led to the fundamental insight that cells sense and respond to various signals encoded in materials, ranging from biochemical to mechanical cues. The biomaterial design for cell encapsulation is becoming more sophisticated in controlling specific aspects of cellular phenotypes and more precise down to the single cell level. This recent progress offers a paradigm shift by designing single cell-encapsulating materials with predefined cues to precisely control donor cells after transplantation.  more » « less
Award ID(s):
2143857
PAR ID:
10532609
Author(s) / Creator(s):
; ;
Publisher / Repository:
Adv Drug Deliv Rev
Date Published:
Journal Name:
Advanced Drug Delivery Reviews
Volume:
201
Issue:
C
ISSN:
0169-409X
Page Range / eLocation ID:
115010
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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