A novel, selective and high‐yielding palladium‐catalyzed carbonylative arylation of a variety of weakly acidic (p
This content will become publicly available on August 22, 2025
Samarium diiodide (SmI2) is a privileged, single-electron reductant deployed in diverse synthetic settings. However, generalizable methods for catalytic turnover remain elusive because of the well-known challenge associated with cleaving strong SmIII–O bonds. Prior efforts have focused on the use of highly reactive oxophiles to enable catalyst turnover. However, such approaches give rise to complex catalyst speciation and intrinsically limit the synthetic scope. Herein, we leveraged a mild and selective protonolysis strategy to achieve samarium-catalyzed, intermolecular reductive cross-coupling of ketones and acrylates with broad scope. The modularity of our approach allows rational control of selectivity based on solvent, p
- Award ID(s):
- 2002158
- PAR ID:
- 10535434
- Publisher / Repository:
- American Association for the Advancement of Science
- Date Published:
- Journal Name:
- Science
- Volume:
- 385
- Issue:
- 6711
- ISSN:
- 0036-8075
- Page Range / eLocation ID:
- 847 to 853
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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