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Title: Forging structural complexity: diastereoselective synthesis of densely substituted β-lactams with dual functional handles for enhanced core modifications

A novel and highly diastereoselective NBS-mediated cyclization ofN-alkoxy α,β-unsaturated silyl imino ethers to furnish nearly three dozen α-bromoN-alkoxy β-lactams with dual functional handles is described.

 
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Award ID(s):
2102462
NSF-PAR ID:
10537041
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Publisher / Repository:
Royal Chemical Society
Date Published:
Journal Name:
Chemical Science
Edition / Version:
Advance Article
ISSN:
2041-6520
Subject(s) / Keyword(s):
beta lactams silyl imino ether NBS
Format(s):
Medium: X Other: PDF
Sponsoring Org:
National Science Foundation
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