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Title: Toward Lung Ventilation Imaging Using Hyperpolarized Diethyl Ether Gas Contrast Agent
Abstract Hyperpolarized129Xe gas was FDA‐approved as an inhalable contrast agent for magnetic resonance imaging of a wide range of pulmonary diseases in December 2022. Despite the remarkable success in clinical research settings, the widespread clinical translation of HP129Xe gas faces two critical challenges: the high cost of the relatively low‐throughput hyperpolarization equipment and the lack of129Xe imaging capability on clinical MRI scanners, which have narrow‐bandwidth electronics designed only for proton (1H) imaging. To solve this translational grand challenge of gaseous hyperpolarized MRI contrast agents, here we demonstrate the utility of batch‐mode production of proton‐hyperpolarized diethyl ether gas via heterogeneous pairwise addition of parahydrogen to ethyl vinyl ether. An approximately 0.1‐liter bolus of hyperpolarized diethyl ether gas was produced in 1 second and injected in excised rabbit lungs. Lung ventilation imaging was performed using sub‐second 2D MRI with up to 2×2 mm2in‐plane resolution using a clinical 0.35 T MRI scanner without any modifications. This feasibility demonstration paves the way for the use of inhalable diethyl ether as a gaseous contrast agent for pulmonary MRI applications using any clinical MRI scanner.  more » « less
Award ID(s):
1905341
PAR ID:
10547211
Author(s) / Creator(s):
; ; ; ; ; ; ; ; ; ; ; ;
Publisher / Repository:
Wiley-VCH
Date Published:
Journal Name:
Chemistry – A European Journal
Volume:
30
Issue:
25
ISSN:
0947-6539
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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