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Title: Chromatin Organization during C. elegans Early Development
Embryogenesis is characterized by dynamic chromatin remodeling and broad changes in chromosome architecture. These changes in chromatin organization are accompanied by transcriptional changes, which are crucial for the proper development of the embryo. Several independent mechanisms regulate this process of chromatin reorganization, including the segregation of chromatin into heterochromatin and euchromatin, deposition of active and repressive histone modifications, and the formation of 3D chromatin domains such as TADs and LADs. These changes in chromatin structure are directly linked to developmental milestones such as the loss of developmental plasticity and acquisition of terminally differentiated cell identities. In this review, we summarize these processes that underlie this chromatin reorganization and their impact on embryogenesis in the nematode C. elegans.  more » « less
Award ID(s):
1923206
PAR ID:
10548820
Author(s) / Creator(s):
;
Publisher / Repository:
MDPI
Date Published:
Journal Name:
DNA
Volume:
4
Issue:
1
ISSN:
2673-8856
Page Range / eLocation ID:
64 to 83
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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