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Background: In the US, obesity is an epidemiologic challenge and the population fails to comprehend this complex public health issue. To evaluate underlying obesity-impact patterns on mortality rates, we data-mined the 1999-2016 Center for Disease Control WONDER database’s vital records.Methods: Adopting SAS programming, we scrutinized the mortality and population counts. Using ICD-10 diagnosis codes connected to overweight and obesity, we obtained the obesity-related crude and age-adjusted causes of death. To understand divergent and prevalence trends we compared and contrasted the tabulated obesity-influenced mortality rates with demographic information, gender, and age-related data.Key Results: From 1999 to 2016, the obesity-related age-adjusted mortality rates increased by 142%. The ICD-10 overweight and obesity-related death-certificate coding showed clear evidence that obesity factored in the male age-adjusted mortality rate increment to 173% and the corresponding female rate to 117%. It also disproportionately affected the nation-wide minority population death rates. Furthermore, excess weight distributions are coded as contributing features in the crude death rates for all decennial age-groups.Conclusions: The 1999-2016 data from ICD-10 death certificate coding for obesity-related conditions indicate that it is affecting all segments of the US population.
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Code and data for "Climate change-induced peatland drying in Southeast Asia"
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Following the global regulation of legacy PFAS molecules, fluorotelomer molecules have been widely employed as replacements to PFOS in aqueous film-forming foam (AFFF) and PFOA in other products. Recent field studies indicate that fluorotelomer molecules are increasingly identified in environmental settings including groundwater, soil and sediments. Consequently, gaining a comprehensive understanding of the fate and transport of fluorotelomers in soils and sedimentary environments is vital. In this study, the behavior of two different fluorotelomers, 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTS and 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTC, in three common soil minerals (kaolinite, montmorillonite and illite) having quite different interfacial properties are reported using molecular dynamics simulations. The interfacial adsorption and dynamical characteristics of 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTS and 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTC vary substantially between the three minerals. Irrespective of the mineral composition, 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTS exhibits surface complexation while 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTC coordinates only with neutral and low charged clay minerals. In addition, the fundamental interactions that dictate the adsorption, interfacial structure of 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTS and 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTC are completely different for the three minerals. The large, aggregated clusters of 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTS at the surface experienced greater stability for longer periods of time and restricted mobility than 6[thin space (1/6-em)]:[thin space (1/6-em)]2 FTC for all three clay minerals. Importantly, the current study provides cluster size dependent diffusion behavior of surface adsorbed fluorotelomer molecules in each clay mineral. Such detailed mechanistic insights are necessary to understand the environmental footprint of fluorotelomers around contaminated sites.more » « less
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Single particle analysis cryo-electron microscopy (EM) and molecular dynamics (MD) have been complimentary methods since cryo-EM was first applied to the field of structural biology. The relationship started by biasing structural models to fit low-resolution cryo-EM maps of large macromolecular complexes not amenable to crystallization. The connection between cryo-EM and MD evolved as cryo-EM maps improved in resolution, allowing advanced sampling algorithms to simultaneously refine backbone and sidechains. Moving beyond a single static snapshot, modern inferencing approaches integrate cryo-EM and MD to generate structural ensembles from cryo-EM map data or directly from the particle images themselves. We summarize the recent history of MD innovations in the area of cryo-EM modeling. The merits for the myriad of MD based cryo-EM modeling methods are discussed, as well as, the discoveries that were made possible by the integration of molecular modeling with cryo-EM. Lastly, current challenges and potential opportunities are reviewed.more » « less
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Abstract Ectomycorrhizal (EM) associations can promote the dominance of tree species in otherwise diverse tropical forests. These EM associations between trees and their fungal mutualists have important consequences for soil organic matter cycling, yet the influence of these EM-associated effects on surrounding microbial communities is not well known, particularly in neotropical forests. We examined fungal and prokaryotic community composition in surface soil samples from mixed arbuscular mycorrhizal (AM) and ectomycorrhizal (EM) stands as well as stands dominated by EM-associatedOreomunnea mexicana(Juglandaceae) in four watersheds differing in soil fertility in the Fortuna Forest Reserve, Panama. We hypothesized that EM-dominated stands would support distinct microbial community assemblages relative to the mixed AM-EM stands due to differences in carbon and nitrogen cycling associated with the dominance of EM trees. We expected that this microbiome selection in EM-dominated stands would lead to lower overall microbial community diversity and turnover, with tighter correspondence between general fungal and prokaryotic communities. We measured fungal and prokaryotic community composition via high-throughput Illumina sequencing of theITS2(fungi) and16SrRNA (prokaryotic) gene regions. We analyzed differences in alpha and beta diversity between forest stands associated with different mycorrhizal types, as well as the relative abundance of fungal functional groups and various microbial taxa. We found that fungal and prokaryotic community composition differed based on stand mycorrhizal type. There was lower prokaryotic diversity and lower relative abundance of fungal saprotrophs and pathogens in EM-dominated than AM-EM mixed stands. However, contrary to our prediction, there was lower homogeneity for fungal communities in EM-dominated stands compared to mixed AM-EM stands. Overall, we demonstrate that EM-dominated tropical forest stands have distinct soil microbiomes relative to surrounding diverse forests, suggesting that EM fungi may filter microbial functional groups in ways that could potentially influence plant performance or ecosystem function.more » « less
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For many years, CI has tried to show the value of computational techniques for response to hazard events but has yet to see success outside of post-hoc analyses. Meanwhile, emergency management (EM) has been struggling to cope with the impact of computation. This duality wherein we know technology can be useful yet also complicates EM (and has not yet been fully integrated into EM) is what we dub the technology crisis in EM. To begin to address this crisis and revitalize CI, we argue that it is necessary to develop an inventory of what technologies EM is competent with and to design training that can extend that competency. This research reports a survey of EM Practitioners in the United States. We offer one of the first inventories of EM technologies and technological skills and identify how current EM technological integration issues are a crisis.more » « less
